Green Coffee Bean Extract
Coffee beans are not strictly speaking beans but green seeds found inside the bright red fruit of the coffee plant.
Roasting the seeds turns them brown and creates coffee’s characteristic aroma and flavor. When the beans are roasted, however, their caffeine content increases but chloreic and chlorogenic acid levels decrease.
To create green coffee bean extract, on the other hand, coffee beans are soaked in water rather than roasted. Soaking the seeds causes fermentation and enables the chloreic and chlorogenic acids to remain intact. Subsequently, green coffee bean extract contains more chlorogenic acids than regular coffee.
These chlorogenic acids act as antioxidants and are the foundation for the many health benefits green coffee beans offer.
Green coffee bean extract is used as a natural treatment for diabetes, high blood pressure, and metabolic syndrome. But, clinical research on the ingredient is limited and often poor quality.
Some evidence suggests the polyphenols found in green coffee bean extract inhibit oxidation and protect against cellular damage. Researchers believe the polyphenols may reduce the risk of death from coronary heart disease.
Furthermore, both animal studies and human preliminary trials demonstrate green coffee bean extract inhibits fat accumulation. The combination of both caffeine and chlorogenic acid found in green coffee bean extract showed a tendency to reduce visceral fat and body weight. Some researchers believe this is because green coffee bean extract modifies hormone secretion and glucose tolerance.
Based on the limited research available, green coffee appears to be safe for most adults.
Consumers should note that green coffee bean extract contains caffeine, though in smaller concentrations than regular coffee. Consequently, green coffee bean extract can cause caffeine-related side effects such as insomnia, nervousness, restlessness, nausea, increased heart rate, and similar symptoms.
Oral contraceptives interact negatively with caffeine, reducing the body’s ability to break down and eliminate the chemical.
Due to limited research on green coffee bean extract, a standardized dosage has not yet been determined.
However, some researchers found taking 93-185 mg green coffee bean extract daily may lower blood pressure in patients with mild hypertension.
For weight loss, evidence suggests 700-1050 mg dosages may be effective.
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 M.G.L Hertog, MSc, E.J.M Feskens, PhD, D Kromhout, PhD, M.G.L Hertog, P.C.H Hollman, MSc, M.G.L Hertog, M.B Katan, PhD. ”Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study” The Lancet, Volume 342, Issue 8878, 23 October 1993, Pages 1007–1011. http://dx.doi.org/10.1016/0140-6736(93)92876-U.
 Cornelis, Marilyn C; El-Sohemy, Ahmed. “Coffee, caffeine, and coronary heart disease.” Current Opinion in Lipidology: February 2007 – Volume 18 – Issue 1 – p 13-19. doi: 10.1097/MOL.0b013e3280127b04.
 Johnston KL, Clifford MN, Morgan LM. “Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice.” American Journal of Clinical Nutrition. 2003;78(4):728–733.
 Abernethy DR, Todd EL. “Impairment of caffeine clearance by chronic use of low-dose estrogen-containing oral contraceptives.” Eur J Clin Pharmacol. 1985;28(4):425-8.
 Kazuya Kozuma, Shigemi Tsuchiya, Jun Kohori, Tadashi Hase and Ichiro Tokimitsu. “Antihypertensive Effect of Green Coffee Bean Extract on Mildly Hypertensive Subjects.” Hypertension Research (2005) 28, 711–718; doi:10.1291/hypres.28.711.
 Joe A Vinson, Bryan R Burnham, Mysore V Nagendran. ”Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects.” Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. Published Date January 2012 Volume 2012:5. Pages 21 – 27. DOI: http://dx.doi.org/10.2147/DMSO.S27665