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2018's 10 Best
L-Glutamine Supplements

L-Glutamine – Non-Essential Amino But Essential For Health

L-glutamine (often just referred to as glutamine) is a conditionally essential amino acid. It has many vital functions from helping to remove harmful ammonia in the blood to aiding and supporting normal brain and gut function.

L-glutamine is especially vital in times of stress or during and after illness. If our body’s glutamine stores are decreased during these times of increased stress, we are more prone to infection. We are also prone to losing muscle mass, and we may see a decrease in the efficiency of other bodily functions.

What is L-Glutamine?

L-glutamine is a versatile amino acid molecule with a large number of benefits and functions in your body. See the #1 L-Glutamine Supplement now.

A Conditionally Essential Amino Acid

L-Glutamine Molecule

L-glutamine is a conditionally essential amino acid. Amino acids are molecules in our bodies that are used to build enzymes and other proteins. L-glutamine is the most abundant amino acid, so it is essential for regular protein and enzyme function.

Essential amino acids are amino acids that our bodies cannot produce and must be obtained in our diet, especially in times of stress. Conditionally essential amino acids typically are produced by the body. But some people suffer deficiencies in which they are unable to produce enough of the amino acid. This appears to be most common in people suffering from serious illnesses. In this case, it is essential to get glutamine through diet or supplementation.

A Neurotransmitter

In addition to being used in our bodies to build proteins, L-glutamine also functions as a neurotransmitter. Neurotransmitters are molecules in our bodies that allow neurons (nerve cells) to send signals to each other. This means that glutamine is not only important for your muscles but also for brain and cognitive function.

An Energy Source

Amino acids are often used in our bodies in a process known as gluconeogenesis. This involves the creation of glucose (a simple sugar) from scratch. Our bodies do this when our blood glucose levels are low, and we need energy. Also, this is the normal way that certain cells in our bodies (e.g. cells in our brains and intestines) get energy.

Because of this effect, it is believed that glutamine helps to stabilize blood sugar levels over time. This is in addition to supporting the proper functioning of our brains and intestines by providing them needed energy.

How does L-Glutamine work?

L-glutamine has many functions, and each of its functions works by way of a different mechanism. Below are some of the most important functions of L-glutamine and the mechanisms for each.

Muscle Building

Muscle Building

L-glutamine is the most common amino acid in our bodies. This is because it is used a lot in proteins and tissues that are particularly protein rich, like muscle. When building muscle, then, it makes sense that we will need a lot of glutamine. But glutamine is also necessary for other bodily functions.

If there isn’t enough glutamine in our blood, our bodies begin a process called catabolism. This is the breaking down of large molecules (in this case, the proteins in our muscles) to use the pieces in other places in the body.

Muscle catabolism can undo the work you put into building and maintaining your muscles. That is why supplementing with L-glutamine is not only important for building muscle, but also for maintaining it. See the #1 L-Glutamine Supplement now

Digestive Support

Our bodies use a lot of glucose. We even use glycogen, a molecule made up of many glucose molecules, to store energy. Because of this, we sometimes need to find sources for glucose other than the glucose in our diets. One source is the glucose that our cells make. In our intestines, enterocytes use glutamine in this way as a source of energy and as a means to prevent fatigue. Our kidneys and brains can also create glucose in this way.

If we aren’t getting enough glutamine, many parts of our bodies, including our digestive system, can suffer the consequences. There is also some evidence that glutamine may aid digestion in other ways. For example, it may support our bodies in creating the proper amounts of mucus, but more research is needed to confirm these findings.

Recovery from Injury and Chronic or Severe Illness

L-Glutamine is constantly being used in our bodies. Normal function in multiple systems is dependent on proper blood glutamine levels. When our bodies undergo trauma or severe stress or illness, cortisol levels increase in our bodies and glutamine stores can be depleted at the same time. This is one of the reasons why we often feel sick after we experience a lot of stress, and why athletes often catch illnesses after grueling workouts or intense performance. Supplementing with L-Glutamine can alleviate some of these symptoms and lead to enhanced recovery.

In addition to general stress, recovery from trauma and damage to muscles specifically can be alleviated by L-Glutamine supplementation. This is simply because our bodies have to make more protein when protein rich tissues like muscles are damaged, and when our bodies need to build protein, glutamine is one of the amino acids that is highest in demand.

Immune System Support

Just as our bodies use L-glutamine for energy in intestinal and brain cells, our bodies’ defense cells (leukocyte) also use glutamine for energy. Because of this, keeping glutamine levels up is essential to maintain a healhty immune system. This is especially true in times of stress when our glutamine stores are often running low.

What Foods Have L-Glutamine?

Meat And Dairy

L-glutamine is found in any food you eat that has protein. It is most abundant in whey and casein protein, as well as meat, eggs, tofu, and certain grains like corn and rice. If you have a low protein diet, or find it hard to get enough protein in your diet, you could be glutamine deficient.

Why Should I Take L-Glutamine?

You should use L-glutamine if you don’t get enough in your diet. You should also consider it if you suspect your glutamine levels are depleted because of stress, injury, or illness. Finally, you should consider it if you perform intense regular exercise. See the #1 L-Glutamine Supplement now

Because some of the causes of low glutamine levels are hard to plan on, it might be a good idea to have some glutamine on hand in case you need it. In addition to helping you keep your glutamine levels up, many people use glutamine to help them with the effects of other conditions. Many of glutamine’s positive effects are well proven. In addition to those, there are many suspected positive effects that L-glutamine may have that need more research. As a safe and effective supplement, glutamine may be worth a try if you have any of the following conditions:

  • Neuropathy (Nerve pain)
  • Stomach Ulcers
  • Ulcerative colitis
  • Crohn’s disease
  • Depression
  • Irritability
  • Anxiety
  • Moodiness
  • Insomnia

What Dose Should I Take?

Glutamine dosages can vary widely from person to person and from use to use. If you’re new to glutamine and your doctor has not already recommended a dose, start with 1-3 grams a day. It can either be divided into doses of 500 to 750 mg or taken all at once. You can then build up your dose until you feel the effects that you want.

People who use glutamine for recovery from intense exercise or to treat chronic disease may want to start with a higher dose. This can be around5-6 grams, and it can be increaseed by larger increments. If you are taking much more than 20 grams a day, talk to a physician before increasing your dose. As with all supplements, stop using and consult a physician if you experience any unwanted side effects.

What Are The Side Effects?

Because L-glutamine is found in large amounts in the body, normal supplementation is usually accompanied by no or few side effects. In the cases where side effects occur, they are usually minor, and may include the following:

  • Stomach or intestinal problems (nausea, vomiting, stomach pain, gas)
  • swelling in your hands or feet
  • muscle, joint or back pain
  • headache
  • dizziness
  • tired feeling
  • mild skin rash or itching
  • dry mouth
  • runny nose
  • increased sweating
  • chest pain
  • hearing problems
  • signs of an infection (fever, chills, sore throat, etc.)

Is L-Glutamine Safe?


Yes! L-glutamine is found in the food you already eat. There just isn’t enough of it to meet your needs. In addition, your body makes L-glutamine every day in an effort to provide your organs with a little extra useful glutamine. L-glutamine is both natural and safe. However, some people should avoid supplementing with extra glutamine. Interactions with certain drugs and conditions are not well known or are suspected to be negative. See the #1 L-Glutamine Supplement now

Children and pregnant or breastfeeding women should not take L-glutamine unless a doctor suggests it. Also, elderly people, people with kidney or liver disease, a history of having had Reye’s syndrome, or with psychiatric disorders or seizures should make sure to talk to a physician prior to using glutamine. Some researchers believe extra glutamine could have negative effects on these conditions.

Are There Any Medications I Can’t Take With L-Glutamine?

L-Glutamine may interact with some drugs you might be taking. So if you are using any medications it might be a good idea to consult a doctor about the effects of L-glutamine supplementation. Also, if you are taking a medication that is designed to decrease blood ammonia levels (like lactulose) or that is part of a chemotherapy treatment regimen, consult your doctor prior to supplementation with glutamine.

What Should I Look For In My Supplement?

L-Glutamine powder may be sold as either a pure powder or in pills. When looking at a brand to purchase, don’t go for anything that has any ingredient other than glutamine and either gelatin or cellulose for the capsule. In some supplements, it might be necessary to see the occasional other ingredient but not with L-glutamine.

Also, make sure you get a supplement that offers the right amount of glutamine. Dosages can vary enormously with glutamine, so decide what dose size is appropriate for your needs before buying. Pill forms will usually offer less glutamine both in total and per dose. But they can be easier to take, which is important because some brands can taste unpleasant. Check reviews to see how tolerable the taste of a particular brand is if you’re going with the powder form.

Best L-Glutamine Supplements

Our top 10 list of L-glutamine supplements is organized to reflect what you most value in your supplements. First and foremost is quality. All of our top ten supplements meet high standards of quality and come from brands with a proven record in excellence and purity. Another important factor in deciding the top ten was cost. You don’t have to pay through the nose to get a high-quality L-glutamine supplement. In addition, all the companies represented on our list have stellar records with customer service and prompt shipping. This ensures that your supplement experience is enjoyable from the first click to your final dose.


  1. Bergstrom J, et al. http://jap.physiology.org/content/36/6/693 Intracellular Free Amino Acid Concentration in Human Muscle Tissue. Journal of Applied Physiology. 36:6. (1974): 693-697.
  2. Axe, Dr. Josh. https://draxe.com/l-glutamine-benefits-side-effects-dosage/ S10 L-Glutamine Benefits, Side Effects & Dosage. Dr. Axe. July 21, 2017. Accessed August 11, 2017.
  3. Examine.com. https://examine.com/supplements/glutamine/ Glutamine – Scientific Review on Usage, Dosage, Side Effects. Examine.com. July 09, 2017. Accessed August 14, 2017.
  4. http://www.webmd.com/vitamins-supplements/ingredientmono-878-glutamine.aspx?activeingredientid=878 GLUTAMINE: Uses, Side Effects, Interactions and Warnings. WebMD. Accessed August 14, 2017.
  5. http://aminoacidstudies.org/l-glutamine/ L-glutamine. Amino acid studies. Accessed August 14, 2017.
  6. https://www.everydayhealth.com/drugs/glutamine. Glutamine – Side Effects, Dosage, Interactions. EverydayHealth.com. August 05, 2017. Accessed August 15, 2017.

#1 - Nutricost L-Glutamine

The Standout: High Quality For Low Cost

Nutricost's L-Glutamine ranks #1 on our list, since it provides a pure and simple way to replenishing glutamine stores and improve recovery after high-level training sessions. Without any additives, this formula provides 5 grams of L-glutamine at a very affordable price. And it is made in the USA at a quality GMP-assured facility.

  • 5 Grams L-Glutamine
  • 100 Servings Per Bottle
  • Great For Stacking
  • Helps With Muscle Recovery
  • Boosts Digestive Health

L-glutamine has been shown to improve muscle recovery, prevent muscle breakdown, reduce exercise-induced muscle soreness, and support a positive nitrogen balance. In addition to reducing muscle catabolism and muscle weakness, glutamine also supports a strong immune system and ideal intestinal health.

Easily mixed into your favorite beverages, this supplement is great for stacking with other supplements or use as a stand-alone product. It provides a multitude of benefits. With well over 100 5-star reviews on Amazon, it's easy to see why people find Nutricost's L-Glutamine perfect for their regimen to enhance overall health.

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#2 - XPI Raw L-Glutamine Powder

The Standout: Single Ingredient for Easy Customization

XPI Raw L-Glutamine is the amino acid that's perfect for building and retaining muscle. With no other ingredients or additives, XPI Raw offers an easy solution for customizing your own supplement regimen. Offering 5 g of nothing but glutamine, XPI Raw's L-Glutamine is the #1 trainer recommended supplement and our #2 choice for the best glutamine options on the market.

  • 5 Grams L-Glutamine
  • 100 Servings Per Container
  • Great for Customizing & Stacking
  • Build & Retain Muscle
  • Improves Digestion

Glutamine is essential to the creation and function of enzymes and proteins in the body. It is also essential for recovery in times of extra stress on your body like those days when you hit it extra hard at the gym. With 500 grams of pure glutamine, XPI Raw's L-Glutamine is exactly what your body needs to build more muscle, get more energy, and recover faster.

With only L-glutamine and nothing else in the bottle, XPI Raw can help you build up your vitamin and supplement routine for peak health and fitness.

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#3 - CoreSeries BCAA Glutamine

The Standout: Clean Formula For Quick Recovery

CoreSeries BCAA Glutamine is a simple five-ingredient product specifically formulated to boost recovery time, performance, and hydration. Complete with 8 Grams of BCAAs in a 2:1:1 ratio, along with 5 Grams of L-glutamine, BCAA Glutamine provides additional building blocks that make recovering between workouts quicker than ever.

  • 5 Grams Glutamine
  • 8 Grams BCAA 2:1:1
  • 1 Gram Hydration Complex
  • 30 Servings Per Bag
  • Boost Recovery Time

Glutamine is a non-essential amino acid, but it essential when it comes to recovery. Glutamine reduces the rate of leucine oxidation while increasing the absorption of leucine in skeletal muscle, enhancing protein synthesis for muscle repair. Glutamine is also the fuel for leukocytes, or white blood cells, so it helps boost immunity and quell inflammation.

With a total of 14 grams of ingredients designed to stimulate protein synthesis, reduce muscle fatigue, and increase post-workout muscle growth, Coreseries BCAA Glutamine is bound to be exactly what you need to help you perform your best.

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#4 - BPI Sports Best Glutamine

The Standout: Diverse Source Of Glutamine

Minimize muscle catabolism with the right essential amino acid for recovery after intense training. BPI Sports’ Best Glutamine is formulated with 6 advanced forms of glutamine in a 6.5-gram blend to support the building of lean muscle, enhance the replenishment of glycogen, and boost the immune system as well as performance.

  • 6.5 Grams Of Glutamine
  • 50 Servings Per Bottle
  • Promotes Protein Synthesis
  • Supports Quick Recovery

Glutamine is the most abundant free amino acid and plays a variety of essential roles, including protein synthesis, nitrogen transport, and immune function. After an intense and grueling workout, glutamine levels are lowered, causing slow recovery. With proper glutamine supplementation, you can help your body recover and rebuild much more effectively.

Best Glutamine is available in several delicious flavors and supplies enough glutamine to increase recovery time and gain lean muscle mass.

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#5 - Cellucor COR-Performance Glutamine

With a focus on providing a potent L-glutamine formula, Cellucor's COR-Performance Glutamine is specifically designed to support muscle recovery and restore glutamine levels with 5 grams of glutamine. As a versatile supplement, COR-Performance Glutamine is easy to stack with other workout supplements, while preventing the breakdown of muscle.

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#6 - GAT Essentials L-Glutamine

GAT Essentials L-Glutamine is a pure pharmaceutical-grade powder designed to support the building of lean muscle mass and enhance recovery after workouts. Supplying 5 grams of L-glutamine, GAT chooses to use the purest and most potent compounds that have been HPLC-tested to improve your physique and increase overall athletic performance.

GAT L-Glutamine is unflavored, making it easy to add to your favorite pre- or post-workout shake, BCAA supplement, or just water for immediate recovery support. The opportunities are endless!

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#7 - Universal Nutrition Glutamine Powder

If you prefer an easy-to-take powder over swallowing capsules, Universal Nutrition's Glutamine Powder is for you. It delivers an ultra-pure, super concentrated dose of 5 grams of high-quality, highly bioavailable glutamine, designed for rapid disintegration and maximum absorption. Take this glutamine powder daily to increase energy, maximize muscle growth, and enhance recovery. Keep Reading »
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#8 - Gluta-Blast

Having bioavailable glutamine helps enhance absorption and concentration levels of L-glutamine in muscle tissue. ProMera Sports' Gluta-Blast aims to do just that with their blend of high-performance glutamine analogues in a 3.1 gram glutamine blend for improved recovery response, enhanced immune function, and increased protein synthesis. Keep Reading »

#9 - Optimum Nutrition Glutamine Powder

Formulated to offer fast muscle repair from high levels of exercise-related exertion, Glutamine Powder by Optimum Nutrition harnesses the power of glutamine to help support your recuperation post workout. With 5 grams of pure, unflavored L-glutamine in every serving, this glutamine powder is easy to mix and extremely versatile. It can be added to any protein shake or beverage. Keep Reading »

#10 - Dymatize Nutrition Glutamine Micronized

Dymatize Nutrition Glutamine Micronized delivers 4500 mg of pure L-glutamine in every serving. It has been laboratory tested for quality and purity and works by removing environmental toxins inside your body as well as boosting optimal brain and muscle tissue function. Each scoop will not only speed up your recovery and replenish vital muscular amino acid stores, but it will also increase the glycogen inside you to help you become stronger and bigger than ever before. Keep Reading »

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