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2018's 10 Best
Joint Supplements

Joint pain manifests itself in a variety of ways and for a variety of people. It seems almost indiscriminate about who it decides to affect and in what ways. This can be extremely frustrating for people who are used to pushing themselves physically.

It’s almost essential to invest in a joint supplement if you are a bodybuilder, powerlifter, runner, or any kind of athlete. If you’re ready to see our list of the best joint supplements, go ahead and jump straight to our list. If you’d like to know a little more about joint supplements to help inform your decision, though, stick around for a bit.

The reasons joints hurt vary. Possible culprits are arthritis, bursitis, and tendonitis.

Arthritis shows up in a few ways. The most common type for athletes is osteoarthritis. This is caused by the wear and tear to your cartilage, which directly affects how your joints move. Rheumatoid arthritis is more of a chronic condition caused by an overactive immune system that is known to attack joints.

Bursitis is when the bursae sacks (which are present in all joints) become inflamed and infected. This causes swelling and pain and can make movement much harder. When people talk about things like “tennis elbow,” they are experiencing bursitis.

Tendonitis affects bodybuilders especially. It’s one of the easiest conditions to treat and prevent. But it often goes untreated, which can lead to permanent injury. If you are known to “work through the pain” even when it’s joint pain, it is likely you are experiencing this. It’s caused by micro injuries to the cartilage that go untreated and get overworked.

The first step to treat painful joints is to rest. For example, replacing your evening racquetball session with a slow run around the track so your elbow can heal. Or skipping a leg day or two. If you have rested for quite a while and are not noticing changes, please go see your doctor and make sure your issue is not more serious.

It is worth pointing out that some joint pains can be avoidable with proper warmups. This is mostly in cases in whichthe problem isn’t serious. If, however, you have confirmed with the doctor that it is a serious issue, a joint supplement may help to alleviate your pain. Supplements can help rebuild the strength in your joints, but your body needs to be able to absorb the nutrients properly. If you keep pushing it on an injured joint, no amount of nutrients or medicine will help it heal.

One of the best things you can do is make sure that your blood is working its way to and through the joint. This allows nutrients from your food, supplements, and medications to make their way to the joint and do some actual work. While walking or running on a bad knee isn’t the greatest idea, going for a swim or rowing might be just what you need to get blood flowing through your joints.

As you probably know, the bloodstream is where all the nutrients from food and supplements are carried through your body. They’re broken down in your stomach. The essentials are then absorbed into your bloodstream, and then they are carried to the parts of your body that need them. So if you have a good combination of blood flow and the right ingredients, you can be sure that there is a healing process happening.

That being said, finding the right supplements for any ailment can sometimes be annoying. It’s time consuming and can be frustrating if you don’t know exactly what to look for. That’s why we’re here to help. This article will give an overview of joint supplements and what to look for when purchasing one.

What Should I Look For in a Joint Supplement?

When you’re looking for the right product, the first thing you’ll want to know is what ingredients are used and how. For joint pain, thankfully, there are a handful of ingredients that have been shown to help all three of the ailments listed above. This makes your job a lot easier because there are a few places where you really can’t go wrong. These ingredients include the following:

  • Glucosamine
  • Omega-3’s
  • MSM
  • Chondroitin

The inclusion of these essentials will increase the chances that you see results, and the side effects will be less likely. Here is a closer look at these ingredients.


Glucosamine comes in several forms, but not all forms are created equal. Each form of glucosamine has a different bioavailability or effect on cartilage, muscle, and bone health. A dose of glucosamine chondroitin or glucosamine sulfate will be most effective in its impact on your strength and pain.

Glucosamine has been sold for a very long time all over the world as a joint supplement. It is considered to be a drug and nutraceutical. In vitro and in vivo studies have proven glucosamine actionable against joint issues. This is especially true in the treatment of articular issues (e.g. cartilage, synovial membrane, and subchondral bone). (1)

It is mostly known for its impact on joint pain in particular. It has been proven to be better than anti-inflammatory drugs like ibuprofen. It doesn’t work as fast, granted, but the effects are longer lasting and impacts are more permanent.

Ibuprofen is the most common form of pain relief. When compared to glucosamine it unsurprisingly failed to provide any lasting impacts. Glucosamine is great for relieving pain and setting up long-term structures for healthy growth. (2)

Glucosamine is typically more bioavailable than other ingredients. And it has repeatedly been shown to work successfully. As with many other supplements, it has a few pals that it works well with, including omega-3s, MSM, and chondroitin.


You may already know this one, but omega-3 fatty acids are a fantastic source for joint support. They have been discussed as one of the best natural ways to combat arthritis in any form. This is because of the way it interacts with several parts of your biology.

Omega-3s are polyunsaturated fats. They are considered separately from other types of fats because of the double bond at the end of the carbon chain. This sets them apart because it makes them more bioavailable for your body, and that helps make every part of them helpful. (3)

Omega-3s have three parts: ALA, DHA, and EPA. Only DHA and EPA have been shown to have continual positive impacts on the body, and they are the only ones found in sources like fish oil or krill oil.

Both DHA and EPA are influential in reducing inflammation, especially in joints. It does so by improving blood flow through the area. Increased blood flow means you will get more nutrients to that area. Omega-3’s can be helpful because they contain a lot of essential nutrients that are great for cartilage, muscle, and bones. (4)

Omega-3s can help your joints get feeling back to normal while you improve the way they function.


MSM is short for methylsulfonylmethane. That’s a mouthful though, so we just call it MSM. It’s recommended to older generations whose joint problems are associated with degeneration. Studies have shown it capable of rebuilding cartilage quickly and painlessly, while giving relief to its users. (5)

This drug is still being investigated, but it has some of the most prominent joint health research available. (6)

MSM has built a reputation for reducing inflammation and being an antioxidant. This is because of the high sulfuric quality and density in its chemical makeup.

Its antioxidant qualities are especially important because they help reduce the level of free radicals in your system. Free radicals feed into degenerative and immune disorders and can wreck your joints.


Chondroitin is typically used to reduce the feeling of stiffness and swelling in your joints. It can do this because it is an animal-based chemical that improves water absorption in your muscles and joints. It is similar to Glucosamine in that it helps rebuild the flexibility of your joints.

It isn’t as bioavailable as glucosamine, but experts will often recommend taking these two supplementally in combination with each other as a way to improve overall joint health.

Both of these supplemental ingredients are also derived from animal tissue. Chondroitin is especially taken from the joints. It is typically found in the gristle of meats, but at that it is in very low concentrations. You will have better luck getting this from a supplement, and you will see better results than if you just up your meat intake.

What Joint Supplements Work Best?

Most joint supplements have several ingredients that have studies warranting their use. There are a lot of choices, and unfortunately, some of them may be less effective than an ice pack and some good old-fashioned rest. We took the liberty of compiling a list of things to look for when deciding what works best for most people. This should help you make an educated decision when the time comes.

Do Joint Supplements Work?

Yes, they typically work very well. They are better when coupled with proper dieting and exercise, but many can bring relief without it. They won’t solve all your problems, especially if your problems are bad enough to warrant medication. When coupled with proper medication and direction from your doctor, you will likely see great results.

Oral Vs. Topical Joint Supplements

Your choice here depends on how your symptoms manifest and what medications you are currently taking for your joints. If you are taking prescribed medications, a topical cream might work best for you.

Our top 10 list only recommends one of those, and that’s because Nutricost’s topical cream is made with MSM, menthol, and lavender. It is a perfect addition because it treats the symptoms of bad or decaying joints but doesn’t interact with other medications. It also works much faster. The effects aren’t as long-lasting as some of the other supplements, though. It will increase blood flow to the area, giving you an excellent way to bring nutrients in. But if you’re looking for something to fix joints from the inside, you might prefer an oral supplement.

We have a lot more oral supplements on our list because even though they’re slower acting, the results are longer lasting.

Single Ingredient Vs. Multiple

This is likely the hardest part about picking the right supplement. Most supplements will contain several ingredients. That’s not always a bad thing. For example, take a look at our top-rated supplement. Oxycollasyn contains 13 active ingredients. Each of these has some proven studies behind their abilities to help reduce joint pain and build strength in the area.

Aside from that, there are single-ingredient supplements that are a great help, but they’re not always the most potent. There’s a benefit to having more ingredients. If one part doesn’t work, you’re not out an entire product. It is more likely that it will work, and it is more likely that there are several pieces that are working toward building strength.

Are There Any Side Effects?

It depends on the product. Mostly this falls to whether or not you’re prone to having reactions to any of the ingredients. Mild skin irritations (topical cream) or gut discomfort (oral supplement) may occur. Keep in mind that these side effects are not common. Still, if you notice any excessive reaction, we would recommend that you stop using the supplement and call your doctor if the symptoms don’t go away.


Our top 10 list of joint supplements is organized to reflect what you most value in your supplements. First and foremost is quality. All of our top ten supplements meet high standards of quality and come from brands with a proven record in excellence and purity. Another important factor in deciding the top ten was cost. You don’t have to pay through the nose to get a high-quality joint supplement. In addition, all the companies represented on our list have stellar records with customer service and prompt shipping. This ensures that your supplement experience is enjoyable from the first click to your final dose.


  1. Henrotin, Y., Mobasheri, A., & Marty, M Is there any scientific evidence for the use of glucosamine in the management of human osteoarthritis? Arthritis Research & Therapy, 14(1), 201. http://doi.org/10.1186/ar3657
  2. Müller-Faßbender, Hans, et a Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee. Osteoarthritis and cartilage 2.1 (1994): 61-69.
  3. Carl J. Lavie MD, Richard V. Milani MD, Mandeep R. Mehra MD, Hector O. Ventura MD Omega-3 Polyunsaturated Fatty Acids and Cardiovascular DiseasesJournal of the American College of Cardiology Volume 54, Issue 7, 11 August 2009, Pages 585-594
  4. Philip Carder Polyunsaturated fatty acids, inflammation, and inflammatory diseases 2006 American Society for Clinical Nutrition Am J Clin Nutr June 2006 vol. 83 no. 6 S1505-1519S
  5. Xu, G., Zhou, T., Gu, Y., Wang, Q., Shariff, M., Gu, P., … Rao, J. Evaluation of the Effect of Mega MSM on Improving Joint Function in Populations Experiencing Joint Degeneration. International Journal of Biomedical Science?: IJBS, 11(2), 54–60. (2015)
  6. Elsa Mével, Laurent-Emmanuel Monfoulet, Christophe Merceron, Véronique Coxam, Yohann Wittrant, Laurent Beck, Jérôme Guicheux Nutraceuticals in joint health: animal models as instrumental toolsDrug Discovery Today Volume 19, Issue 10, October 2014, Pages 1649-1658

#1 - Oxycollasyn

The Standout: Clinically-Tested Ingredients

Oxycollasyn is a high-quality joint supplement with four key patented ingredients, along with several natural herbs, vitamins, and minerals to assist with all kinds of joint conditions. With powerful, all-natural ingredients, each dose can enhance joint mobility, reduce joint pains, rebuild damaged cartilage, and prevent future joint-related conditions.

  • 375 mg KollaGen II-xs™
  • 375 mg Glucosamine Sulfate
  • 100 Mg Chondroitin Sulfate
  • Minimize Joint Pain

KollaGen II-xs™ is a patented form of chicken collagen type ll, which uses special water extraction techniques to reserve all nutrients. Collagen helps promote cartilage repair, along with dampening inflammation for pain relief. Glucosamine sulfate and chondroitin sulfate are popular ingredients that are used in a multitude of joint supplements, and combined, each contribute to restoring cartilage health, boosting mobility, and reducing pain.

Glucosamine is typically extracted from the exoskeleton of shellfish and is a precursor to proteoglycans and glycosaminoglycans, which make up the cartilage found within joints, ligaments and tendons, and other connective tissue. Chondroitin is a naturally-occurring component of connective tissue, and it's primary function to stimulate cartilage production.

With several powerful ingredients, Oxycollasyn is formulated to restore flexibility and mobility, while giving you a protective advantage for overall joint health.

Keep Reading »

#2 - Joint Cream

The Standout: Soothing Topical Cream

Nutricost's Joint Cream with Menthol is a high-quality, fast-acting topical cream that utilizes ingredients like MSM to help fight inflammation to soothe joint and muscle pain. Use it in conjunction with other joint healing supplements for maximum benefits, or use it alone as a gentle pain relief aid.

  • 4 Oz Per Bottle
  • Made With MSM
  • Made With Menthol
  • Includes Lavender
  • Soothe Joint Aches

Menthol has natural analgesic (pain-relieving) properties by binding to opioid receptors to produce a numbing effect. Menthol also produces vasodilation, which increases blood flow to the area for quick healing. Lastly, the cooling effect of menthol also helps soothe the uncomfortable heat sensation that inflammation produces.

MSM is a potent inflammation regulator, and is utilized in joint supplements, since cartilage uses sulfur for methionine production. MSM is also useful for immune function and is tied to accelerated healing and pain reduction by counteracting the buildup of lactic acid.

If you're looking for a joint health supplement to add to your arsenal, Nutricost's gentle but potent joint cream is the perfect addition.

Keep Reading »

#3 - GAT Essentials Joint Support

The Standout: Well-Suited For Athletes

Designed to support overworked joints, GAT Essentials Joint Support offers bodybuilders, athletes, and other active individuals relief from that pain and stress. Featuring the use of glucosamine and chondroitin in this premium formula, Essentials Joint Support can help rebuild and strengthen cartilage to enhance overall performance and improve bone health.

  • 1.5 Grams Glucosamine
  • 500 mg Chondroitin
  • 250 mg Collagen
  • 60 Tablets Per Bottle

Essentials Joint Support provides high doses of glucosamine and chondroitin, the two big players in most joint supplements. Both help to combat joint pain by helping rebuild cartilage, improve mobility, and reduce inflammation. This supplement is an effective alternative to non-steroidal inflammatory drugs like ibuprofen.

GAT Joint Support also contains collagen to support healthy cartilage growth and strengthen overworked joints. Natural extracts such as Boswellia prevent painful inflammation and swelling, cushioning joints to help bodybuilders and athletes achieve peak performance.

Joint Support is ideal for those who train hard, push their body to the limit, and need a strong supplement that will help support joints while providing ample recovery and pain relief.

Keep Reading »

#4 - Universal Nutrition Animal Flex

Animal Flex is rock-solid support for ligaments, tendons, and joints, designed for the professional or everyday athlete. Every dose of Animal Flex delivers powerful complexes of ingredients such as glucosamine, cetyl myristoleate, ginger root, and turmeric extract that combine all of these complexes into one well-rounded formula to relieve joint soreness that comes with long and intense training regimens. Keep Reading »

#5 - Scivation Flexatril

Designed to improve your joint health, Scivation Flexatril is formulated with with clinically-tested and patented ingredients to provide your joints with needed support. One featured ingredient is Sensoril, a patented version of ashwagandha. Ashwagandha has been shown to help relieve stress as well as arthritis, and combined with other stress and inflammation-reducing ingredients, Flexatril helps boost overall joint health. Keep Reading »

#6 - Futurebiotics Inflammotion

Futurebiotics Inflammotion offers a 100% natural, vegetarian formula utilizing a unique combination of ingredients like Chinese skullcap and Acacia extract. Years of hard workouts and everyday activities can wear cartilage down, causing pain or discomfort. Fighting inflammation at the root cause of degeneration can help soothe aches and enhance mobility. Keep Reading »

#7 - Zenwise Health Advanced Strength Joint Support

Zenwise Health Advanced Strength Joint Support uses classic ingredients like glucosamine (1500 mg) and chondroitin sulfate (1200 mg), along with MSM and curcumin to help strengthen joints, and promote healthy tissue and cartilage. This powerful joint supplement helps reduce aches, pains, and overall joint discomfort. Keep Reading »

#8 - Vimerson Health Ultra Flex Joint Support

Vimerson Health Ultra Flex Joint Support is designed to alleviate joint pain and inflammation. Glucosamine Sulfate, the primary ingredient in this complex, has been reported to reduce the rate of collagen degradation found in joint tissue. MSM, another big player, has been shown to decrease joint inflammation and restore collagen production. This powerhouse complex could be just what you're looking for to support and enhance joint health. Keep Reading »

#9 - Schiff Move Free Advanced Plus MSM

Schiff's Move Free Joint Health supplement was built to support five parts of joint health: flexibility, strength, mobility, comfort, and lubrication. Glucosamine, chondroitin, and MSM are key in the formation of cartilage to support flexibility and cushioning of your joints, while hyaluronic acid supports joint lubrication. Keep Reading »

#10 - Doctor's Best Glucosamine Chondroitin MSM with OptiMSM

Doctor's Best supports joint structure, comfort. and function. Each serving provides 1200 mg of chondroitin sulfate, 1500 mg of glucosamine sulfate 2KCI, and 1000 mg of MSM. This potent combination of three proven ingredients can help build cartilage that is necessary to provide shock absorbency for joints. Doctor's Best can help reduce inflammation and stiffness as well as improve flexibility of joints and rebuild cartilage. Keep Reading »

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