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2018's 10 Best
Glucosamine Supplements

Many of us notice as we get older that waking up in the morning gets increasingly difficult. Instead of bounding out of bed, we are met with stiff and sore joints. And getting into the kitchen to make a cup of coffee feels like a feat. Recovery time from the gym or other strenuous activities takes longer.

Age is not the only factor. Joint injury and disease often leads to inflammation and deterioration of joint cartilage. Conditions that produce joint pain include osteoarthritis, rheumatoid arthritis, strains, and sprains. Joint pain can be acute, only lasting days or weeks, or chronic, lasting months or years.

We may all wish to find the fountain of youth to revert back to pain-free days. But this is not realistic. Given that, the next best solution is utilizing quality anti-inflammatory and anti-aging sources. An example of such a supplement is glucosamine.

What Exactly Is Glucosamine?

Glucosamine Molecule

Glucosamine is a naturally-occurring precursor to nitrogen containing amino sugars. It is also a precursor to proteoglycans and glycosaminoglycans. These make up the cartilage found in joints, the spine, ligaments, tendons, and other connective tissue. This protective chain of proteins and fat acts as a lubricant for joints. In turn, this allows for easy and functional movement. See the #1 Glucosamine Supplement now

Glucosamine Hydrochloride or Sulfate?

There are two types of glucosamine that are often sold on the supplement market. These are glucosamine hydrochloride and glucosamine sulfate. Both contain glucosamine as the only active ingredient. The only difference is the delivery vehicle–either the hydrochloride or sulfate acid. The effectiveness of delivery depends entirely on the amount of hydrochloride or sulfate acid present.

Both are beneficial in providing joint pain relief. However, glucosamine sulfate is the most recommended and highly researched. Sulfate is also naturally-occurring in the body. And it is critical for the formation or rebuilding of cartilage. This makes glucosamine sulfate even more advantageous in supporting joint health. However, more recent studies suggest that glucosamine hydrochloride can hold its own. [1]

Don’t Let Stiff Joints Make You Crabby


Glucosamine Sulfate is also naturally occurring in the chitin exoskeleton of shellfish, including crab, lobster, and shrimp. Most manufacturers extract the Glucosamine Sulfate rich shells and process it for easy and convenient oral consumption.

Technically, you can also eat shellfish shells. But many find them to be unappetizing if not downright unappealing. It is also difficult to get the same concentration of glucosamine sulfate organically. This is because it is found in trace amounts. In contrast, supplements typically contain up to 1500 mg per serving. See the #1 Glucosamine Supplement now

Traditional Treatments Vs Glucosamine

Conventional treatment for joint pain is limited to nonsteroidal anti-inflammatory drugs. These include ibuprofen or aspirin. In more severe cases, opioids may be prescribed. These options may provide pain relief. But they are also associated with side effects ranging from mild to severe.

NSAIDS have been shown to increase risk for heart attack or stroke. They may also damage the stomach lining, resulting in ulcers or bleeding. And they have been linked to renal failure. [2]

Other common side effects include:

Glucosamine Medication
  • Constipation
  • Diarrhea
  • Headache
  • Drowsiness
  • Heartburn
  • Nausea
  • Vomiting
  • Dizziness
  • High Blood Pressure
  • Liver Problems
  • Allergic Reactions

Glucosamine sulfate has been shown to be just as effective as medicine for arthritis and joint pain. And it has less severe side effects than conventional prescription treatments. See the #1 Glucosamine Supplement now

NSAIDS only offer pain relief and may exacerbate existing inflammation. In contrast, glucosamine addresses the root cause of joint pain. One study compared glucosamine sulfate to Ibuprofen. The researchers measured reported pain scores of the participants. In the first two weeks, the Ibuprofen group reported greater decreases. But by week 4, the group receiving glucosamine sulfate was doing significantly better than the ibuprofen group. [3]

Physicians rating the overall response as good or fair rated 44% of the glucosamine sulfate-treated patients as good. This compared to only 15% of the ibuprofen group. Glucosamine may not be as initially potent in terms of pain relief as Ibprofen. But after several weeks, the results are comparable. And glucosamine aids in repairing damaged joints and surrounding tissue. [3]

Does Glucosamine Have Side Effects?

Most glucosamine sulfate supplements are derived from shellfish. As such, those with a shellfish allergy may want to take caution. However, it has been shown that most shellfish allergies are associated with the meat of shellfish, and not the shell. This may mean that some individuals with a predisposed shellfish allergy may be able to tolerate glucosamine sulfate. But there are also non-shellfish derived glucosamine supplements available for those that do not want any risk.

Glucosamine may also cause mild digestive issues. These include stomach pain, constipation, diarrhea, indigestion, or nausea. There is some evidence that Glucosamine may (in high doses) alter insulin and blood sugar levels. So those with diabetes may want to consult with their primary care physician before taking glucosamine. [4]

Recommended Dosage And Instructions

It is recommended that one standard oral dose of 1500 milligrams (or divided into three 500 mg doses) of Glucosamine yields the best results. These are typically seen after 6-8 weeks of use. For those who weigh 200 pounds or more, a standard dose of 2000 milligrams may be more effective. [5] See the #1 Glucosamine Supplement now

Topical glucosamine creams are also available. They can be applied to tender areas, for additional pain relief and reduced inflammation.

Other Benefits Besides Joint Pain Relief

Glucosamine Gut Health

Glucosamine has also shown promising results with promoting gut and colon health. It may help by healing intestinal permeability. When there is an opening in the intestinal lining, certain undigested proteins from food get passed into the blood steam. This triggers inflammation or auto-immune responses. The progressed inflammation can trigger stomach and bowel issues. And it can also worsen existing inflammation in other parts of the body. Glucosamine can be especially beneficial for those living with Chron’s disease or ulcerative colitis. [6] Best Glucosamine Supplements

Our top 10 list of glucosamine supplements is organized to reflect what you most value in your supplements. First and foremost is quality. All of our top ten supplements meet high standards of quality and come from brands with a proven record in excellence and purity. Another important factor in deciding the top ten was cost. You don’t have to pay through the nose to get a high-quality glucosamine supplement. In addition, all the companies represented on our list have stellar records with customer service and prompt shipping. This ensures that your supplement experience is enjoyable from the first click to your final dose.


  1. Owen Bond. https://www.livestrong.com/article/201337-what-is-glucosamine-hci/ Glucosamine HCL Vs. Glucosamine Sulfate for Joints. Livestrong.com Oct 03, 2017.
  2. Sherine E. Gabriel, MD, MSc; Liisa Jaakkimainen, MSc; Claire Bombardier, MD. http://annals.org/aim/article/705145/risk-serious-gastrointestinal-complications-related-use-nonsteroidal-anti-inflammatory-drugs Risk for Serious Gastrointestinal Complications Related to Use of Nonsteroidal Anti-inflammatory Drugs: A Meta-analysis. Annals of Internal Medicine.
  3. Müller-Faßbender, Hans, et al. http://www.sciencedirect.com/science/article/pii/S106345840580007X Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee. Osteoarthritis and cartilage 2.1 (1994): 61-69.
  4. Anderson, J. W., R. J. Nicolosi, and J. F. Borzelleca. http://www.sciencedirect.com/science/article/pii/S0278691504003321 Glucosamine effects in humans: a review of effects on glucose metabolism, side effects, safety considerations and efficacy. Food and Chemical Toxicology 43.2 (2005): 187-201.
  5. http://www.mayoclinic.org/drugs-supplements/glucosamine/dosing/hrb-20059572 Glucosamine. Mayoclinic.com Nov. 01, 2013.
  6. Yomogida, Shin, et al. https://www.spandidos-publications.com/ijmm/22/3/317 Glucosamine, a naturally occurring amino monosaccharide, suppresses dextran sulfate sodium-induced colitis in rats. International journal of molecular medicine 22.3 (2008): 317-323.

#1 - Glucosamine Sulfate

The Standout: Best Value For Cost

Ranking #1 is Nutricost's Glucosamine Sulfate, designed to deliver 1.5 Grams of pure glucosamine sulfate in every serving. Formulated to help minimize joint pain, boost mobility, and help rebuild damaged cartilage, Nutricost's Glucosamine Sulfate is quality for the price. Just 7 Cents per serving, each capsule ensures premium glucosamine sulfate to help rejuvenate joints.

  • 1.5 Grams Per Serving
  • 120 Servings Per Bottle
  • 7 Cents Per Serving
  • Support Joint Health
  • Minimize Inflammation

Glucosamine has been shown to hinder the rate of collagen degradation by reducing inflammation signalling to the affected area. This is especially vital in providing joint pain relief and supporting overall joint health.

Glucosamine can also help regulate blood sugar levels, since it is similarly structured to glucose. It interferes with glucose absorption by competitively inhibiting glucose transporters. This induces insulin resistance over the short term.

Nutricost's Glucosamine is a high-quality glucosamine supplement, designed to help control inflammation and support joint health. Sold at a reasonable price, you can save even more by taking advantage of Amazon's two day shipping with Prime.

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#2 - VitaBreeze Glucosamine

The Standout: Triple Strength All-Inclusive Formula

Vitabreeze's Glucosamine is a triple-strength formula that combines potent doses of glucosamine, chondroitin, MSM, and turmeric for the ultimate inflammatory joint health support. Each ingredient has been carefully selected and encapsulated in an easy-to-swallow capsule for your convenience. Made with no GMOs, fillers, or preservatives, it's no wonder Vitabreeze has come in as a close second on our list.

  • 1.5 Grams Glucosamine
  • 1 Gram Chondroitin
  • 600 Mg MSM
  • 300 Mg Turmeric
  • 250 Servings Per Bottle

The addition of chondroitin, MSM. and turmeric makes Vitabreeze's Glucosamine triple strength when fighting against joint discomfort. Chondroitin is often used in conjunction with glucosamine to provide joint support, while MSM (Methylsulfonylmethane) provides necessary sulfur to aid in collagen synthesis. Lastly, turmeric is a potent anti-inflammatory to help reduce inflammation and ease joint pain.

Vitabreeze's Glucosamine is a potent joint supplement, and one of the few brands that blend all four powerful ingredients to make a triple-strength formula.

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#3 - Zenwise Health Joint Support

The Standout: Highly Researched And Trusted Formula

Zenwise Health's Joint Support combines 1500 mg of glucosamine with chondroitin, MSM, and hyaluronic acid to target joint-related issues. This unique blend promotes healthy joints, boosts joint mobility, and enhances natural joint lubrication. Each daily dose can help you regain the active lifestyle you seek and reclaim moving with ease. Each bottle is also manufactured in a GMP-certified facility, making it a joint supplement you can trust.

  • 1.5 Grams Glucosamine
  • 1.2 Grams Chondroitin
  • 1 Gram MSM
  • 25 Mg Hyaluronic Acid

Each tablet contains glucosamine and chondroitin to help fortify joints, and prevent gradual degradation of cartilage and tissue, while MSM helps enhance the reformation of collagen via collagen synthesis for prime joint support. Hyaluronic acid has also been added in this formula to help cushion and lubricate joints for easier mobility.

Zenwise has undergone extensive research into joint health. This led to this advanced joint support supplement, formulated with all-natural ingredients to improve and maintain overall joint health.

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#4 - Schiff Glucosamine

If you're looking for a high-potency glucosamine supplement, Schiff's Glucosamine is 83% glucosamine vs the industry standard of 65%. Hyaluronic acid is also included to help protect and cushion joints. Each easy-to-swallow tablet is specifically designed to ensure joint health and adequate lubrication for easy movement. Keep Reading »

#5 - BulkSupplements.com Glucosamine HCL

BulkSupplements.com stands out on this list due to their powdered form of glucosamine HCL. Each pouch provides -glucosamine hydrochloride in any easy-to-mix formula that can be conveniently added to any beverage. Joint care supplementation has never been this simple. This clean and pure powder contains no fillers, sugar, soy, yeast, gluten, or additives. Each batch is also lab-tested for guaranteed purity. Keep Reading »

#6 - Now Glucosamine '1000'

Now Glucosamine '1000' delivers 1 gram of glucosamine per capsule, designed to support healthy joint function. Glucosamine enhances cartilage formation, which means glucosamine supplementation tackles the root problem in joint pain instead of just solely treating the symptoms. Each bottle contains no GMOs and is GMP certified, making Now Glucosamine a crowd favorite. Keep Reading »

#7 - Puritan's Pride Glucosamine Sulfate

Puritan's Pride Glucosamine Sulfate is a rapid-release formula engineered to enhance joint health, support cartilage maintenance, and boost mobility. Void of all fillers, allergens, and additives, this glucosamine sulfate supplement is perfect for those who desire extra nutritional support for their joints. Keep Reading »

#8 - Solgar Glucosamine Hyaluronic Acid Condroitin MSM

Glucosamine Hyaluronic Acid Condroitin MSM is a shell-fish free glucosamine supplement, perfect for those who have shellfish allergies but still want the benefits of glucosamine. This extra-strength formula includes joint health inducing ingredients, included to minimize joint pain and inflammation. Keep Reading »

#9 - Nature's Way Glucosamine

Nature's Way Glucosamine is a premium-quality glucosamine supplement that provides 500 mg of glucosamine per capsule. Glucosamine is a precurosor to glycosaminoglycans, which help build healthy cartilage. Each serving promotes healthy joints and mobility, while remaining gluten, soy, yeast, wheat, corn, and dairy free. Don't let stiff joints keep you from enjoying every day. Keep Reading »

#10 - Doctor's Best Glucosamine Sulfate

Doctor's Best Glucosamine Sulfate rounds out our list of top glucosamine supplements. A combination of 750 mg glucosamine, 600 mg chondroitin, and 500 mg MSM, each capsule helps provide the shock-absorbing cushion healthy joints need. This science-based nutrition can help restore youthfulness and vitality, allowing movement to be a breeze. Keep Reading »

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