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2018's 10 Best
Depression supplements

According to the Anxiety and Depression Association of America, over 40 million adults are affected by anxiety, depression, or both. These are the most common mental disorders in the United States. These disorders especially affect people of color, but will often go undiagnosed in men or POC populations. Women are more likely to be diagnosed than men, although it is more often attributed to hormone disorders.

In many cases the negative effects of SSRI’s and other mood affecting drugs scare off people who would benefit from taking them.

Fortunately for those people there are some natural substances that can assist with mood, sleep, and stress levels if the problem is not severe. Substances like Folic Acid, GABA, Omega-3’s, St. John’s Wort, Tryptophan, or B Vitamin Complexes can be great for helping boost your mood.

In cases of Seasonal Affective Disorder B Vitamins and Tryptophan have especially been recommended as treatment options because they’re a greataddition to your regular diet anyways.

Top brands have come up with mood complexes or created products specifically designed to boost your mood and improve overall health.


Our top 10 list of Depression supplements is organized to reflect what you most value in your supplements. First and foremost is quality. All of or top ten supplements meet high standards of quality and come from brands with a proven record in excellence and purity. Another important factor in deciding the top ten was cost. You don’t have to pay through the nose to get a high quality supplement. In addition, all the companies represented on our top ten list have stellar records with customer service and prompt shipping to ensure that your supplement experience is enjoyable from the first click to your final capsule.

#1 - Mood Complex

The Standout: Contains 300mg of St. John’s Wort

Improving your mood and feeling better can be a long complicated process, or it can be a short and relatively easy step. Nutricost’s Mood Complex takes the confusion out of improving mental health by providing you a solid multivitamin chock full of beneficial vitamins and minerals.

  • 90 Capsules Per Bottle
  • Non-GMO and Gluten Free
  • Includes a B vitamin complex
  • 500IU of Vitamin D
  • 90-Day Money Back Guarantee

There aren’t many top notch supplements out there that will provide you with a solid base in improving mood and relieving stress. Nutricost’s mood complex will provide you with essential vitamins and minerals so you can feel better physically and mentally.

Try Nutricost’s Mood Complex risk free today! We guarantee this product with a 90-day money back guarantee.

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#2 - Zhou CALM NOW

The Standout: Herbal Blend for Mood Boosting and Relaxation

There are many situations where a “chill pill” is necessary, especially if you struggle daily with anxiety and depression. Zhou CALM NOW is a cost effective and all natural option that is guaranteed 100% vegan and cruelty free.

  • 100% Vegan and Cruelty Free
  • 60 Capsules per bottle
  • Contains several forms of B Vitamins
  • Reduce anxiety and boost your mood
  • Money Back Guarantee

It can be easier to take on your daily tasks with CALM NOW. Enjoy the relaxing, focus improving effects of this premium blend of quality ingredients. This contains passion flower, ashwagandha, lemon balm, and so much more!

Take care of your mind and body and give it the support it needs to really feel better.

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#3 - Natrol 5-HTP Time Release Tablets

The Standout: Time Release Tablets

If you’re looking for something quick, but effective in boosting serotonin so you can feel better mentally and physically, Natrol 5-HTP Time Release Tablets will provide you the support you need.

  • Better Sleep and Controlled Appetite
  • Feelings of Calm
  • 100% Drug Free
  • Balance Serotonin Levels
  • All Natural

Although mainly to be used to help improve your mood, stress levels, and comfort 5-HTP is a great way to lose weight appropriately. It will curb your appetite and help you stick to a cleaner and healthier diet!

Feeling better can be easy with Natrol 5-HTP.

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#4 - LES Labs Mood Boost

You can cover all your mood boosting bases with this awesome product! LES Labs’ Mood Boost is chock full of 5-HTP, L-Theanine, and magnesium, which are essentials in promoting mental and physical health! You also have great all natural ingredients like passionflower and ashwagandha root!

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#5 - NutraHerbals’ Organic Ashwagandha Root Powder

Ashwagandha root is recommended as a way to reduce stress and improve mood quickly and without side effects. NutraHerbals’ Organic Ashwagandha Root Powder guarantees that you are getting organic ashwagandha root powder with added pepper to improve absorption. Each capsule is extra strength, with 1200MG per serving!

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#6 - NOW Mood Support

NOW Mood Support is a great supplement to bring into your daily regimen. With commonly used and well known ingredients like, St. John’s Wort, B Vitamins, Calcium, and Magnesium. You can work to improve your mood and reduce feelings of stress efficiently with this awesome product!

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#7 - NatureWise 5-HTP Plus+

5-HTP is one of the leading products for boosting serotonin levels and improving mood and mental well-being. NatureWise 5-HTP Plus+ is a brilliant concoction of 5-HTP and Vitamin B6, the leading vitamin in promoting mental health. This product can not only enhance your overall mood, but help manage serotonin levels, appetite, and a solid sleep schedule!

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#8 - Genius Joy

This Genius formula is built to be a natural rival for antidepressants, and don’t let the price shock you! With the inclusion of SAMe, N-Acetyl L-Tyrosine, Rhodiola 5Plus, Red Panax Red Ginseng, and a Neurofactor, Genius Joy is the proud brainjoy of the Genius Brand. Learn to hack into your system to improve mood and focus daily with a natural product.

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#9 - Arazo Nutrition 5-HTP

This 5-HTP supplement is a great, non-GMO, drug free, and plant based amino acid that has been built to enhance mood, relaxation, and sleep. Arazo Nutrition 5-HTP is a brilliant way to build up serotonin levels so you can try to move past feelings of depression and anxiety!

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#10 - VitaStrength St. John’s Wort

St. John’s Wort is a #1 recommended ingredient for any mood boosting products. VitaStrength St. John’s Wort is created to give you this awesome, all natural substance so you can start to improve your mood and health. St. John’s Wort is a great way to promote healthy brain chemical balancing where needed!

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