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2018's 10 Best
CLA Supplements

The world knows CLA for its fat-burning capabilities. What many don’t realize though is that it’s capable of improving other aspects of your life than just body composition.

CLA is an acronym for Conjugated Linoleic Acid. It is considered to be an Omega-6 fatty acid. Most people associate omega-6 fatty acids with bad health, and this is because they’re often found in overly-processed and high-fat foods. Americans especially are known for having too much omega-6 in their systems and it leads to many negative health impacts.

The difference between CLA and other omega-6 fatty acids though is that CLA is polyunsaturated which means the molecular chain contains a double bond, which changes the way it interacts in your body. It is seen to act more like an omega-3, which everyone knows is good for you, rather than your typical omega-6.

Because so many people have so much of the omega-6 fatty acids in their systems, the idea of taking more seems to contradict their ideas of improving health. But unlike other omega-6’s, there’s not a hard line on how much of this you can take before it’s bad for you, and you can actually just take more CLA to reduce the negative impacts of other omega-6’s.

CLA is typically found in beef and sheep products, which includes both, meat and dairy. You’ll have the best luck finding it in products labelled “grass-fed” or that are “whole fat” and “organic”. This is because the processing is different both inside the animal and just prior to being ready to sell.

That being said, there are many kinds of people who fail to get enough CLA into their diets naturally. Whether this is because they’re vegan or vegetarian, or because they have poor eating habits, it doesn’t matter. But what does matter is finding a supplement that is cruelty free, and that has a solid base in CLA (meaning, there’s not a ton of additives) so you can see the best results and feel great about them. Jump to our list of amazing CLA Supplements

Before we can get into that, though, let’s look at what benefits you should expect from the product, the best way to see these benefits, and how much CLA you should take daily to feel your best.

What Are the Benefits of CLA Pills?

When it comes to deciding if you’re going to take a CLA supplement, you need to have a clear idea of what the benefits are and how much you need to reap all those desired benefits.

CLA is one of the top-most dietician-recommended weight-loss supplements available. But aside from weight loss benefits, it has impeccable impacts that, while still being proven, are showing improvements in insulin disorders, managing inflammation, and immune responses within your body.

One note here: there are benefits of CLA that aren’t fully proven or supported by the FDA or any other clinical entity. While there are studies being currently conducted, CLA is a relatively new supplement that still has a ways to go before being considered a cure for any issue. It works best though when paired with proper lifestyle changes.

Weight Loss

Weight loss is the number one reason people take CLA. And this is for a good reason. It is the most highly-studied benefit of CLA, and because it has significant research behind it, many doctors and dieticians feel confident recommending it.

Whether you’re looking to improve your physical appearance or lose fat efficiently, it has great properties that allow it to help. And unlike many of its comrades, it doesn’t eat up muscle. It has actually had a few studies show that it helps to build muscle mass instead.

Typically it is recommended to bodybuilders for this exact reason. When they are in a cut before competition and need the added edge of a muscle pump and fat burn, CLA is a great option. It is also highly recommended for obese people when they are first starting out because it will help prevent muscle burn that can come along in the weight-loss process.

When taking CLA to assist with weight loss, studies have shown that it isn’t always necessary to make complete lifestyle changes in order to see real results. But when coupled with lifestyle changes that are aimed at improving your overall body composition, such as diets or physical activity, it is especially proficient.

CLA works by breaking up the fatty acid bonds that are already packed into your body. By breaking down the bonds it makes it easier for your body to metabolise fats that you already have.

In a study completed in 2009, researchers discovered that while CLA wasn’t great for losing weight overall, it did give results for lowering of overall body fat percentage and an increase in muscle mass (when coupled with exercise).

Raff, Tholstrup, Toubro, etc., etc. wrote in their article, Conjugated linoleic acids reduce body fat in healthy postmenopausal women.:

“In conclusion, a 50:50 mixture of c9,t11- and t10,c12-CLA isomers resulted in less total and lower-body FM in postmenopausal women and greater serum insulin concentrations in the highest waist circumference tertile.” (1)

Which basically means, they found that a mixture of the two types of CLA used was the most effective way to reduce body fat especially around your waist and lower body. Both forms resulted in fat loss and muscle gain, but the one form was 7% more effective than the other.

Both forms were more effective than just diet and exercise alone, which is the real success here. This shows how it can be a great plateau buster, or addition to work that’s already being done to give you an edge. Jump to our list of amazing CLA Supplements

Insulin Support

The impact CLA has on insulin sensitivity is still being heavily researched. But, basically, the idea is that this effect is very similar to how it can affect lipid metabolism. CLA is known to boost glucose metabolism and reduce insulin sensitivity to give you a better response to overall blood sugar in your system.

In a 2002 study done by Riserus, Arner, Brismar, and Vessby for the Department of Public Health in Sweden, they found that in obese patients CLA was able to help reform insulin sensitivity and lipid metabolism.

“Unexpectedly, t10c12 CLA increased insulin resistance (19%; P < 0.01) and glycemia (4%; P < 0.001) and reduced HDL cholesterol (-4%; P < 0.01) compared with placebo, whereas body fat, sagittal abdominal diameter, and weight decreased versus baseline, but the difference was not significantly different from placebo. These results reveal important isomer-specific metabolic actions of CLA in abdominally obese humans. A CLA-induced insulin resistance has previously been described only in lipodystrophic mice.” (2)

So, CLA was able to moderate insulin resistance and glycemia, which are imperative for managing diabetic conditions, and reducing LDL (i.e. bad) cholesterol. It didn’t have as much of an impact on overall weight in this specific study when compared to the placebo, however.

Inflammation, immune health, and liver support.

Immune and liver health are heavily associated with inflammation levels within cells. Many times the search for treatments to some of our most common diseases revolves around the ability to reduce inflammation. In many cases inflammation is a natural response to pain or infection, it’s your body’s response to negative stimulus. But when inflammation becomes chronic, it can end up causing other health issues and is uncomfortable regardless. Jump to our list of amazing CLA Supplements

CLA is a powerful anti-inflammatory, which has been shown to improve immune responses to stimuli and help your liver handle detoxification better.

In a January 2018 study, researchers looked expressly at the anti-inflammatory effects CLA had on bovine mammary epithelial cells. Here’s what they found:

“Bovine mammary epithelial cells were treated with complete medium containing either 50 µM of cis-9, trans-11 CLA (c9,t11 CLA) or trans-10, cis-12 CLA (t10,c12 CLA) or (?)-linolenic acid (aLnA) or (?)-linolenic acid (gLnA) or linoleic acid (LA). . . The results showed that cells treated with fatty acids and LPS increased ROS production compared with control cells. Among treatments, cells treated with c9,t11 CLA and t10,c12 CLA isomers revealed significant lower levels of ROS production compared with other fatty acids.”(3)

What they concluded from this study is that CLA was more effective than the other anti-inflammatory treatments they reviewed. The reason this is, is because CLA triggers a faster cell response to the stimulus, which helps your immune system attack bad cells faster, so the response doesn’t need to be as harsh.

While this was performed on animal cells, this work makes space for more studies (hopefully human) to take place in the future.

You shouldn’t replace prescribed medications with CLA. For mild or budding issues though, it could be a great natural alternative to currently overused products. For example, chronic users of acetaminophen or other acetaminophen -containing products might find this to be a great natural solution to joint or muscle inflammation.

Why CLA Works Best!

If you’ve been searching and searching for answers to some of your health problems, you’ve likely run across a million natural cures that all claim to be the best. CLA is one of our personal favorites because its effects are specific and well-tested.

It compares well to other industry favorites like Safflower Oil, Krill Oil, and regular diet and exercise.

CLA V. Safflower

Surprisingly, this is an issue surrounded by an insane amount of controversy. In 2013, Dr. Oz (oh, that pesky Dr. Oz…) claimed that Safflower Oil is superior to, or at least as good as, CLA in reducing overall body fat and improving health. The CLA community was outraged.

Safflower was cited as a great agent for reducing belly fat following a study which showed that it had impacts on reducing belly fat in subjects without diet or exercise changes. The issue lay in the fact that while there was a definite loss in belly fat, there was no change in overall body fat percentage or BMI in those test subjects.

CLA has been proven to reduce overall body fat, BMI, blood lipid levels, and glucose levels with less than 3 grams a day. Safflower needed 8 grams a day to basically re-adjust where fat sat on subjects bodies.

While safflower does have some apparent other side effects, including:

  • Heart protection
  • Skin and hair care
  • Relieving PMS symptoms

Each of these benefits have ongoing studies being completed to prove them.

The only real benefit that safflower has over CLA is for those opposed to using animal products. CLA is made in animal stomachs and is typically made in practices that vegans might not support. Safflower is an alternative for that measure, but when it comes to what will give you the most bang for your buck, CLA will win 4 out of 5 times. Jump to our list of amazing CLA Supplements

CLA V. Omega-3’s

This, right here, is your big rivalry. Omega-3’s vs. Omega-6’s.

In most any other circumstance Omega-3’s would beat out Omega-6’s with absolutely no issue. Omega-3’s are found in fish-type products like fish oil or krill oil. You can also get them naturally through fish, krill, or many underwater creatures.

Omega-6’s are usually to blame for obesity, high blood lipid content, and other major health issues. They’re typically an issue to be trying to solve in your system. But in the case of CLA, because it is conjugated linoleic acid, it is a better choice specifically for weight loss and other health problems associated with it.

The typical solution to deciding which you should take is to take both.

Having both in regular amounts on a daily basis has the best physical impacts and they work well to balance each other out. Giving you an amazing edge of feeling better altogether.

CLA Supplement V. Diet and Exercise

There’s nothing wrong with wanting to get CLA from a natural source rather than from a supplement. How well that will work for your goals though depends on what you are willing to do to get it.

CLA is made in the rumen processing of animal stomachs. If you know anything about herbivores, you know that many of them have four stomachs, or really one looooooong stomach with 4 parts. Each contribute to a separate processing of food going in so it can be used appropriately throughout the body.

This process is what contributes to the creation of conjugated linoleic acid and can’t be recreated in human stomachs. This makes CLA a form of “essential fatty acid”. Your best bets at getting it are through eating meats and animal-based products.

Which is where many people run into the issue of getting enough of it in a day.

CLA pills are more efficient and have clinical support behind doses. You can’t guarantee that you got 3g of CLA in that beef flank, but you can guarantee you got enough in the pill or oil you took.

As with all products, you can expect results only when you can ensure you’re getting a specified dose. So CLA pills would win out in this case.

Another thing to note here: CLA is typically safe in any dose. So if you’re taking a CLA supplement and are worried about overdosing because you also eat meat, don’t worry. You won’t get near enough to cause any sort of concern.

Side Effects

There are side effects to too much CLA, but it’s worth pointing out that you do need quite a lot of it over an extended period of time to see those side effects.

People have noticed reduced liver function as well as worsening inflammation and a loss in moderation of diabetic conditions. So basically, if you take too much it can cause the problems that you are trying to solve by taking it. Funny, huh?

How Much CLA Should You Take a Day?

This is one of those products that people who maintain a normal, healthy diet aren’t likely to need. You get CLA naturally in beef and dairy products when eaten in moderation. It’s when you’re cutting drastically, as is seen with people struggling with obesity or trying to fit a specific body fat percentage, like is seen in bodybuilding.

When you’re taking a CLA supplement your best bet is to follow the advice of a dietician, or the bottle. But always start off taking smaller doses than recommended by any bottle. This gives you a chance to make sure you won’t react badly to it, and to be able to see the changes clearer.

There is another thing to keep in mind that you will see with our top 10 products. You want to make sure the product you buy contains better than 80% CLA in every capsule or serving. This is the best percentage that people have noticed for optimal fat loss. Jump to our list of amazing CLA Supplements


Our top 10 list of CLA supplements is organized to reflect what you most value in your supplements. First and foremost is quality. All of or top ten supplements meet high standards of quality and come from brands with a proven record in excellence and purity. Another important factor in deciding the top ten was cost. You don’t have to pay through the nose to get a high quality supplement. In addition, all the companies represented on our top ten list have stellar records with customer service and prompt shipping to ensure that your supplement experience is enjoyable from the first click to your final capsule.


  1. Raff, Tholstrup, Toubro, Bruun, Lund, Straarup, Christensen, Sandberg, Mandrup. Conjugated linoleic acids reduce body fat in healthy postmenopausal women.J Nutr. 2009 Jul;139(7):1347-52. doi: 10.3945/jn.109.104471. Epub 2009 Jun 3
  2. Risérus, Arner, Brismar, VessbyTreatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. Diabetes Care. 2002 Sep;25(9):1516-21. Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.
  3. Dipasquale, Basiricò, Morera, Primi, Tröscher, Bernabucci. Anti-inflammatory effects of conjugated linoleic acid isomers and essential fatty acids in bovine mammary epithelial cells. Animal. 2018 Jan 9:1-7. doi: 10.1017/S1751731117003676. [Epub ahead of print]

#1 - CLA

Nutricost's CLA lands the #1 spot due to their high quality, affordable CLA. Each dose provides 800 mg per serving, and with 240 servings per bottle, each serving is only 6 cents. CLA is fatty acids that are necessary in metabolic functions, including lipid metabolism, immune regulation, and inflammation response. Nutricost has formulated their CLA derived from Safflower Oil, and proudly made in the USA. Keep Reading »

#2 - Universal Nutrition CLA

Using their knowledge of the effectiveness that conjugated linoleic acid can provide, Universal Nutrition CLA offers 800mg of the highest quality CLA in each softgel. Studies have found that CLA has an influence over body fat and can help to increase lean mass. With such a positive effect on the body's immune system and capability to utilize antioxidants, CLA uses multiple pathways in which to help you to achieve your fitness goals of fat loss without causing problems that the other stimulant-filled fat burners can generate. Keep Reading »
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#3 - Dymatize CLA

Dymatize CLA is specifically formulated to support fat loss and optimal health for a leaner, fitter body through this naturally occurring fatty acid - conjugated linoleic acid. Delivering 780mg of CLA in each softgel serving, Dymatize CLA can help reduce body fat for a leaner physique, promote lean muscle mass, and enhance the delivery of nutrients throughout the body. Get the fat shredding power that CLA can provide without the extra calories for the fit and healthy body you desire with a healthy lipid profile. Keep Reading »

#4 - Cellucor COR-Performance CLA

Supporting weight loss in a high-quality CLA formula, Cellucor COR-Performance CLA makes for an effective supplement to reduce excess body fat while increasing lean muscle mass. Every 2 softgel serving contains 1600mg of conjugated linoleic acid which can help to boost the efficiency of nutrient distribution and absorption while enhancing exercise performance. Working to utilize food consumption as fuel during exercise, COR-Performance CLA can help you achieve your lean and fit physique. Keep Reading »
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#5 - Optimum Nutrition CLA Softgels

Focusing on producing high-quality conjugated linoleic acid that is found naturally in eggs, red meat, and dairy products, Optimum Nutrition CLA Softgels uses a reputable brand - Clarinol. Every easy-to-swallow softgel serving of CLA Softgels contains 750mg of CLA to stimulate the body's ability to shred fat stores and source out nutrients to the muscle mass in order to create a leaner physique. Perfect for an enhancement in overall health and wellness, CLA Softgels can get you on the path towards achieving your fitness goals. Keep Reading »


Harnessing the weight managing power that conjugated linoleic acid possesses, BSN CLA DNA provides a stimulant free formula using this group of distinct fatty acids. Naturally found within foods such as dairy products and red meat, CLA DNA is designed to support the healthy management of weight and body composition. Each serving provides 750mg of CLA in the form of a softgel for easy swallowing and digesting to help stimulate the process of fat and weight loss without the negative side effects that stimulants can cause. Keep Reading »

#7 - MuscleTech Platinum Pure CLA

Ensuring you get the purest ingredients in the weight loss industry, MuscleTech Essentials Series has produced Platinum Pure CLA an ultra-pure CLA formula to help you attain the weight loss results you desire. Offering anti-catabolic support in every softgel serving, Platinum Pure CLA provides the body with 800mg of pure CLA without the use of stimulants to prevent experiencing negative side effects. Platinum Pure CLA can not only aid in the loss of fat but it can also prevent muscle mass from breaking down.. Keep Reading »

#8 - Sports Research CLA

Sports Research CLA suppies 1250 mg of premium CLA into each veggie gel cap, so you get a higher-potency product for your money. Designed to promote healthy weight management, with no unsafe or stimulating ingredients like caffeine. Each capsule is derived from Non-GMO Safflower and third-party tested to ensure outstanding quality. Keep Reading »

#9 - Nutrex Research Lipo-6 CLA

Designed to help shape a leaner, meaner body, Nutrex Research Lipo-6 CLA offers a stimulant-free formula that can help activate metabolism rates and increase muscle mass. Using a concentrated form of conjugated linoleic acid in combination with regular exercise, Lipo-6 CLA can better assist the body in building lean muscle and utilizing fat stores as energy for better body composition. Stimulate the natural fat shredding process that this powerful 1,000mg CLA Active Blend can provide. Keep Reading »

#10 - NatureWise CLA 1250

NatureWise 1250mg CLA safflower oil capsules can be used as a fat burner, and when combined with exercise, studies suggest that CLA may stimulate the breakdown of stored body fat and block new fat cells from growing. This non-stimulating, all natural weight loss supplement is a safe alternative to diet pills that may carry undesired side effects. Keep Reading »

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