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Side Effects of Nitric Oxide Supplements

Should You Be Worried About Taking Nitric Oxide Supplements?

Nitric oxide supplements have played an integral role in bodybuilding since 1996. These supplements help athletes and fitness enthusiasts alike improve circulation, build muscle, and boost immunity.

Interestingly enough, nitric oxide supplements don’t actually contain nitric oxide (N.O.), which is a gas produced naturally by the body. Rather, these supplements provide various amino acids and other ingredients to spur nitric oxide production.

“To make nitric oxide, enzymes in the body break down the amino acid, arginine,” explains Jim White, spokesperson for the American Dietetic Association.

Then, nitric oxide dilates blood vessels, increasing blood flow and circulation. Improved circulation increases the maximum amount of nutrients and oxygen available to the muscles. More nutrients and oxygen enables the muscles to work harder and longer with reduced fatigue and recovery time.

Nitric oxide supplementation can offer amazing results when the right ingredients are used. Arginine and citrulline (which converts into arginine) are some of the most effective ingredients in the industry.

However, using nitric oxide supplements is a double-edged sword. On one side, you have increased performance and enhanced results, but on the other, you have the risk of negative side effects.

Most Common Nitric Oxide Supplement Side Effects

The most common nitric oxide supplement side effects are primarily minor and include nausea, diarrhea, headaches and stomach problems but there are other potential side effects to be aware of before taking a nitric oxide supplement with some less concerning than others.

1. Increased Urge to Urinate

As mentioned earlier, the amino acid arginine is essential for nitric oxide production. However, consuming excess amounts of arginine often results in more frequent urination.

According to the Food Research International, “In order to produce urine, the body processes liquids into an intermediate stage which is high in the amino acid called arginine. Normally the liver produces enough of the enzyme arginase to convert and concentrate this liquid into urea (urine). When it does not, however, in some people this seems to cause the body to try to expel this high arginine liquid excessively, both day and night.” [1]

How to Regulate This Effect: To avoid this side effect, keep arginine dosages under 5,000 mg a day. Although this might sound like a lot, you could exceed this dosage in three to four servings of an average nitric oxide supplement.

2. Reduced Dopamine Levels

Another potential side effect is a decrease in dopamine. Effective nitric oxide releasers have an inhibitory effect on dopamine transporters, which decreases uptake by as much as 66% [2].

Dopamine, an organic neurotransmitter, is responsible for regulating the following:

  • Motivation levels
  • Healthy sleep cycles
  • Short and long term memory
  • Cognitive skills

By increasing your nitric oxide production, it could have a negative impact on any of the above functions.

How to Regulate This Effect: The amino acids used in nitric oxide supplements typically have little impact on dopamine production, so this side effect is rare. However, you can naturally increase dopamine levels via exercise, dieting, and even participating in sexual activities. Furthermore, the amino acid tyrosine is known to increase dopamine production (when used in safe doses between 250-500 mg daily).

3. Zinc Deficiencies

The amino acid histidine is often featured in nitric oxide supplements. When combined with the amino acid beta-alanine, it creates the compound carnosine. Carnosine is a natural substrate to nitric oxide synthase (the enzyme responsible for nitric oxide production).

However, studies show that high levels of histidine and carnosine are often associated with zinc imbalances and deficiencies. [3]

If you continue to lose zinc, you may suffer from any of the following:

  • Diarrhea
  • Impotence
  • Impaired appetite
  • Delayed sexual maturation

How to Regulate This Effect: The recommended dietary allowance for zinc is 8 mg daily for women and 11 mg daily for men. According experts at WebMD, “The typical North American male consumes about 13 mg/day of dietary zinc; women consume approximately 9 mg/day,” so consuming adequate zinc shouldn’t be problematic for most individuals.

However, if you’re concerned about eliminating too much zinc, then you may consider taking a zinc supplement. You can also consume zinc-rich foods like oysters, pumpkin seeds, peanuts, and crabs.

4. Nausea and Stomach Cramps

Perhaps the most common side effect of nitric oxide supplements is gastrointestinal distress. Many amino acids used to produce nitric oxide have a history of creating digestive problems, particularly arginine.

Experts at Medline Plus explain, “L-arginine is POSSIBLY SAFE for most people when taken appropriately by mouth short-term. It can cause some side effects such as abdominal pain, bloating, diarrhea, gout, blood abnormalities, allergies, airway inflammation, worsening of asthma, and low blood pressure.” [5]

How to Regulate This Effect: While this side effect isn’t too damaging in the long-run, it can make your workout experience unpleasant. To reduce this risk, be sure to follow the directions on your supplement carefully. Some formulas offer the best results with food, while others work best when taken on an empty stomach. Many products divide arginine doses throughout the day to keep side effects to a minimum.

Feel free to take smaller doses of your supplement and then work your way up to the full amount, allowing your body to adjust to the ingredients.

5. Blood Pressure Changes

As mentioned earlier, nitric oxide widens blood vessels to improve circulation and reduce blood pressure. According to the Centers for Disease Control and Prevention, about 1 in 3 US adults have high blood pressure [6], so this side effect may be desirable.

However, if you have mildly low blood pressure, or hypotension, this may result in chest pain, shortness of breath, loss of energy, and even seizures.

How to Regulate This Effect: If you already suffer from hypotension, you may want to think twice about trying a nitric oxide supplement, or at least consult with a doctor first.

Additionally, you should also be sure to increase your fluid intake, since low blood pressure can be exacerbated by mild dehydration.

6. Blood Sugar Changes

Similar to changes in blood pressure, nitric oxide supplements can also affect blood sugar.

According to a study published by the American Diabetes Association, nitric oxide increases glucose uptake during exercise.

“This mechanism is more important in individuals with type 2 diabetes…N.O.-mediated glucose uptake may compensate for impaired insulin action…The N.O. pathway therefore may represent a potential therapeutic target in patients with type 2 diabetes.” [7]

How to Regulate This Effect: Experts at MayoClinic.com exhort diabetics to exercise caution before supplementing with arginine or similar nitric oxide supplements. Blood glucose levels should be carefully monitored by a professional whether you have type 1 or type 2 diabetes.

Additional Arginine Ailments and Side Effects

Touted for its ability to boost nitric oxide levels, the amino acid arginine is one of the most common ingredients found in nitric oxide supplements. Arginine is regarded as safe, but ingesting large quantities may lead to gastrointestinal side effects such as bloating and stomach cramps.

According to the Mayo Clinic, additional side effects include an increased risk of bleeding, change in blood sugar levels, and increased risk of herpes simplex cold sores. [9]

If being treated for low nitric oxide levels via arginine injection, there are some additional side effects to be aware of. These include allergic reactions, itching, or shortness of breath.

Interactions With Medication

Always consult with a doctor before using any nitric oxide supplement as there are dangerous interactions with medications that can occur. Antihypertensive drugs combined with arginine, for example, might cause blood pressure to drop to dangerously low levels.

You should also avoid taking nitric oxide supplements with nitrates or other medications which increase blood flow to the heart. This might cause increased dizziness and lightheadedness. [5]

Are Nitric Oxide Supplements Safe?

While nitric oxide supplements pose a small risk to your health, many products are completely safe when taken as recommended. The above side effects are usually minimal and only affect a small portion of users. As long as you maintain a healthy diet and participate in regular exercise, you can enjoy the benefits nitric oxide has to offer.

However, if you are taking any medications, it’s always best to consult a doctor before adding supplements (nitric oxide or otherwise) to your diet.


    Leave a Comment

    Comments (63)

    gus b

    November 28, 2013

    need to no

    I take opana 10 mg will this NOS synthesis would hurt me in any way


      May 7, 2018


      Can I take Ashwagandha with NO?


      May 8, 2018


      We haven’t heard of any complications resulting from taking both of these kinds of supplements, but to be sure you should check with your doctor.


    May 1, 2014

    Nitic oxcide bcaa and creatine

    Is it bad for me if I take a nitric oxcide product creatine and bcaa?

      Mike Jackson

      Mike Jackson

      May 1, 2014


      First, you should know what each does. Nitric oxide boosters generally contain L-Arginine which increases the body’s production of NO and helps control blood flow. Creatine gives your muscles quick energy by pulling water to your muscles for bigger pumps. BCAAs help to increase muscle growth and energy levels. You can stack these supplements. Most common time frames are: Creatine – Morning & Pre Workout, NO – Pre Workout, BCAAs – During & Post Workout. Make sure you talk to your doctor if you experience any negative side effects, have a history of medical conditions, and/or currently taking medication.


    May 30, 2014

    Great article

    I started taking citrulline after reading how great it was for muscle recovery, energy and blood flow. It worked great at first. Started losing belly fat, firmer erections, and my hair seemed to stop thinning. Citrulline did more than I expected. After about a month I noticed I had to wake up and piss more than usual after taking it. Erections were not as noticeable and it seemed to stop working all together. The best way to describe how I feel now is ‘off’. Decreased motivation and libido and decreased energy levels. After reading this I realize that it must have altered my dopamine levels. I’m stuck in a funk and hoping that the side effects will eventually wear off. Most sites list no side effects for this supplement. Even if it didn’t alter my dopa levels and I’m depressed for some other reason, it still makes me piss like a race horse. Thanks for addressing the side effects. You are one of the few sites that have


      February 13, 2015


      same thing happened to me my memory was all blank my creativity cognitive skills all went from 100 to 0 i felt depressed for long

      September 2, 2015

      Use Lithium to increase Dopamine Levels

      I was having the same issue, my motivation went to sh!t, so I started taking 20mg of Lithium Orotate by Vitamin Research in the morning to help increase my Dopamine levels. It’s also a natural Anti-Depressant so that worked out really well. Another fantastic thing about Lithium Orotate is that it’s the only mineral shown to actually help your brain create new Gray Matter! It’s pretty cheap, Amazon has it for around 20 bucks.
      As for the increased Urination, I started taking Healthy Hair Caps by Vitamin Research Products. It has Saw Palmetto, which helps reduce your urge to urinate. If you want to save some money, you could also use Prostate Plus by Earth’s Creation. It has 500mg of Saw Palmetto and it’s like 1/3rd the price, though not as good for your Hair as the Healthy Hair Caps. I usually take my Saw Palmetto supplements with Dinner.
      One last thing that I think helped A LOT, is Epicor by True Health. This stuff REALLY helps with any Stomach Discomfort. I have a really sensitive stomach and almost anything I took would make me feel bloated and give me cramps. Epicor solved that problem in spades. I usually take one before taking my NO and my Protein Drinks.

      May 14, 2018

      Same Symptoms

      I did the same thing – increased my L citrulline to approx. 4g per day for almost a month. I decided to cycle off and now have little to no energy, head in a fog, lightheaded, difficulty concentrating, mild headaches, low sex drive. Did not know about the dopamine level decrease. I have had these side effects going on day 4 now. I hope it passes soon.


    October 13, 2014

    Can i take Anabolic Rx24 and Nitric Max Muscle with Simvastatin?

    I was advised by my doctor to take Simvastatin for 30 days, to lower my bad cholesterol (LDL) level.

    Incidentally, my order of Anabolic Rx24 and Nitric Max Muscle has just arrived.

    I haven’t asked my doctor yet about this. I haven’t started taken any of the above yet.

    I wanted to be cautious.



    February 24, 2015

    Nitric Oxide Supplement Side Effects

    I’ve been intending to write a review of Nitric Oxide for some time. I purchase Nitric Oxide (Super NOS Pump) and after only a couple of days I could really fill my workout increase and muscles firming up.

    However, it scared me half to death. All of a sudden my memory when almost totally blank, I couldn’t focus, I was dizzy and nearly black out while driving. And felt like my brain had gone numb and I was in a total fog all the time.

    Mind you, I’ve been working out my Entire Life but I’ve never taken any sort of supplement to increase anything.

    I immediately stop taking it, but it took me more than a week or so to recover, get it out of my system and back to normally. I had to travel and give a presentation but I was unable too and a colleague had to stand in for me.

    Be very very careful with this stuff.



    June 18, 2015

    Can nitric oxide cause a stroke

    I began using L-Arginine 1000mg. to lower my blood pressure but I received a suggestion to eliminate it’s use because of possibilities of a stroke after stopping its use over a period of time.

    Is this true?

      Mike Jackson

      Mike Jackson

      June 18, 2015

      Re: Can nitric oxide cause a stroke

      Research has found that Nitric Oxide does play a role in acute stroke. The level of stroke severity and brain injury depend on the levels of Nitric Oxide taken in. An increase of Nitric Oxide is associated with an increase of brain injury and early deterioration of neurological functions. The standard amount of L-Arginine varies and is measured case-by-case. 1000mg of L-Arginine, which equals to 1g of L-Arginine, is on the low end of the dosage spectrum for L-Arginine intake. Talk to your doctor to ask how L-Arginine affects your body and the possibility of experiencing a stroke as they are more familiar with your health and can give you better guidance.

      June 25, 2015

      Can nitric oxide cause a stroke

      Hi Danny,

      Are you taking any food supplements as of now? Recently, I’ve just discovered a food supplement that is good for all ailments. No side effects because it is made up of fruits and vegetables. I’ve been using this supplement for 2months. And viola, my bowel movement changes. Because, before I only poop twice a week but now, I poop every other day. Not bad for taking 1 capsule each day. And also I noticed that it increases my energy and stamina during my workout. If you’re interested to know what I’m talking about, just reply back. Thank you.

    Mikey Bav

    July 9, 2015

    Nitric Oxide

    Great post. Any opinion on this nitric oxide supplememt? http://www.amazon.com/Cellucor-Chrome-Nitric-Oxide-Supplement/dp/B009M3RZXQ Just started taking it and it’s worked well for me so far.

      Mike Jackson

      Mike Jackson

      July 9, 2015

      RE: Nitric Oxide

      If you find that Cellucor’s NO3 Chrome has been working for you, then you’ve found a great formula for yourself. Recently, Cellucor has released an updated version of this product under the G4 Series. The difference? They’ve updated their Extreme Vascularity Complex from 655mg to 750mg and introduced the Nitrosigine┬« brand inositol-stabilized arginine silicate while bumping off L-Norvaline and Pycnogenol, the pine tree extract. This branded compound is arginine bound to silicon which increases the levels of nitric oxide within the body. This may cause you to experience side effects such as those listed above in the article. If you experience any negative side effects, discontinue your use and talk to your doctor immediately.

      July 13, 2016


      Yes I would l I’m ke to know what you are taking

      November 15, 2017

      Need imfo

      I was thinking of getting that nitric oxide but I am concern about the side effects. I have had a mini stroke and do have high blood pressure, short term memory lost. Should I not take that stuff?


      February 15, 2018


      Those would all be great questions for your physician, Joseph. The guidelines on the labels of most of these products dictate that they’re for use with healthy individuals over the age of 18. If you feel like you don’t fall solidly within that category, then you need to be asking these questions.


    August 7, 2015


    I’ve been taking arginine with pine bark extract everyday for about 4 months, do I need to take a break or cycle them

      Mike Jackson

      Mike Jackson

      August 10, 2015

      Re: Larginine

      It is recommended that you cycle your use of Arginine and Pine Bark Extract to prevent possible side effects. While both Arginine and Pine Bark Extract are natural ingredients, it is recommended that you talk to your doctor if you experience negative side effects.


    August 29, 2015

    Side Effects?

    I have always worked out without supplements but being in college I have found that I have less energy so I decided to try preworkout, creatine-free, and I loved it way more than I thought I would. I don’t use it all the time, but I am curious about the side effects now. I use Cellucor N0 Extreme. Would this carry the same side effects? Especially if I only use it once or twice a week?

      Mike Jackson

      Mike Jackson

      September 1, 2015

      Re: Side Effects?

      Depending on your body’s sensitivity in response to Nitric Oxide supplements like Cellucor N.O. Extreme, you may or may not experience these side effects. As you are only using this product once or twice a week, you may not see any of these side effects. It is highly recommended that you speak with your doctor and discontinue your use of your Nitric Oxide supplement if you experience intense side effects.


    September 6, 2015

    Met rx "pumped" workout drink

    I hit the gym today and forgot my extend work out drink. I bought a Met RX Pumped drink at the counter. It read to drink half pre and the rest during. Working out is fairly new for me by the way. During my workout my head began to throb on the right side. It was such an effect that I truly thought I was having a stroke. My head is still not right and feels like a severe headache. I’m assuming I’m sensitive to an ingredient? Has anyone experienced this?


      September 6, 2015


      I should have noted, I am a heavy caffeine drinker so I’m confident it was not the caffeine.

      Mike Jackson

      Mike Jackson

      September 8, 2015

      Re: Met rx "pumped" workout drink

      When you first begin to work out and use potent nitric oxide supplements, it is important to err on the side of caution as your body is not used to the power of many of the ingredients that are used within these formulas. The severe headache you are experiencing may be a result of sensitivity to an ingredient. It is highly recommended that you discontinue your use and talk to your doctor about your side effects especially if they continue or increase.

    Jack Harris

    September 7, 2015

    Stunt in Growth?

    Will this pill stunt my growth
    Im 15 and looking for some mass gains and fat loss!!!
    will this help???

      Mike Jackson

      Mike Jackson

      September 8, 2015

      Re: Stunt in Growth?

      Nitric oxide supplements are NOT intended to be used by anyone below the age of 18 as it may negatively affect the proper growth and development of the body. It is highly recommended that you put your energy towards working out regularly in combination with a healthy diet during this age to help achieve the results you want safely.


    September 8, 2015

    All amino over individual supplementation

    I have read that it is best to take an ALL AMINO rather than individual supplement. And then for specific period before rest from using.


    hesham saeed

    February 24, 2016

    decreased lipido?

    Few of my friends tried NO3 drive from prosupps which is (as mentioned on the label) a nitric oxide amplifier. they reported that while on this supplement, they did not have sexual desire (decreased lipido if you may). I thought I might find that as a side effect for nitric oxide supplementation but I didn’t. Any thoughts?



    February 27, 2016

    Increased seizures

    I have temporal lobe epilepsy that is uncontrolled with meds. I had brain surgery in 2007, it decreased the seizures but didn’t stop them. My mom gave me some l-arginine to help with weight loss and energy. I NEVER should have taken it! Totally memory loss for a week and huge increase in both complex partial and tonic clonic seizures. Avoid it if you have lower seizure threshold!!! Very dangerous!!



    March 21, 2016

    Substitutes for NO3 Chrome

    I love taking NO3 Chrome, I find that I get great pumps at the gym and it really helps with my lifts. The only problem, I tend to be experiencing headaches frequently when using this product. I am looking for a substitute that is similar to this product. Thanks.

      Mike Jackson

      Mike Jackson

      March 21, 2016

      Re: Substitutes for NO3 Chrome

      As the increased production of nitric oxide can cause headaches and even migraines, it is highly recommended that you discontinue your use and talk to your physician about these uncomfortable side effects. While it is difficult to provide an equal substitution to NO3 Chrome, it may help to increase consumption of foods that contain nitric oxide (spinach, beets, carrots, radishes, etc.), L-Arginine (chicken, tuna, soybeans, quinoa, etc.), and L-Citrulline (watermelon, cucumber, garlic, onions, etc.). A reduction of the serving size of NO3 Chrome, may also help reduce headaches.


    March 31, 2016

    Mixing Sups

    Read the ingredient list. A lot of supplements have similar ingredients. You can take a N.O. a protein powder and a creatine sup when they actually all have creatine in them. The same goes with vitamins and minerals. Too much of one of these things can be a bad thing.


    Jose ontiveros

    April 14, 2016

    Feeling great! But I have a question.

    Before I took N.O. I had really bad issues with my hogh blood presure and my heart pule (usually over 90 ), I was taken enalapril and metoprolol for these issues. After reading an article on internet on how N.O. could help you lower your blood presure I decided to give it a try.
    I order Argenine and Citrulline, combined with vitamins E and C, and folic acid. Alpha lipoic acid.
    Well it did work with excellent results, within a week I stop taking my meds and my blood presure is under 120/80 and my heart rate is under 78, I m not longer have any issues with the side effects of my meds ( dizziness, uncontrolled blood presure, headaches, and mood swings) even my sexual activity has increase and I have a lot of energy, I don’t have any issues.
    But today I went for a general physical and my Dr. Found a very small trace of sugar in my urine
    I dont have diabetes but.the Dr. Say it was a very small trace.
    Should I have to be concerned about this or this a side effect that will disaper with time.
    I dont wat to go back to my meds, because the side effects were worst than with N.O.
    Any help with this issue will be very much appreciated.
    Thank you.

      Mike Jackson

      Mike Jackson

      April 21, 2016

      Re: Feeling great! But I have a question.

      First, let me congratulate you on lowering your blood pressure and no longer experiencing negative side effects that you previously experienced on your meds. Making healthy decisions and paying attention to what your body is telling you are the best ways to improve your health. Unfortunately, your concern over whether or not the trace of sugar in your urine is a long-term or short-term occurrence should be discussed with your physician as well as the negative effects you experienced on your meds.

    Will this stunt my growth?

    May 6, 2016


    I’m 18 and 5’9, kind of athletic, not huge muscles but eh. Will this pill be good or bad for me?

      Mike Jackson

      Mike Jackson

      May 6, 2016

      Re: hello?

      Nitric oxide supplements may help to produce the muscle pump and efficient blood delivery your body needs during exercise. However, it is highly recommended that you talk to your doctor before use.


    May 9, 2016

    Need to know

    If I am trying to have a baby with my gf would this supplement affect that ?

      Mike Jackson

      Mike Jackson

      May 10, 2016

      Re: Need to know

      If there are high concentrations of Nitric Oxide in the body, it can negatively affect the reproductive system and sperm functions in men. High levels may cause infertility and damage to the sperm DNA. It is highly recommended that you talk to your physician about your concerns and get your levels of Nitric Oxide checked.

    Fred Muller

    May 27, 2016

    Liver enzymes and damage?

    Hey Mike – I have been taking L-Arginine L-Citrulline for over a year now (1000 mg) by Source Naturals, and recently I have lowered the dose so I can avoid side effects. But this week I just had my labs done and it came back as some of my liver enzymes are going up a lot. Have you heard or read any study about the effects of L-Arg+L-Citru on the liver? Thanks

      Mike Jackson

      Mike Jackson

      June 2, 2016

      Re: Liver enzymes and damage?

      Typically, research has shown that while Nitric Oxide in large doses can damage the liver, the use of L-Arginine has been found to prevent damage and injury. L-Citrulline, on the other hand, has been found to help increase arginine levels. However, it is highly recommended that you talk to your physician about your liver concerns as well as your use of an L-Arginine L-Citrulline supplement and it’s possible interactions.


    June 2, 2016

    does no2 affect urinary analysis tests?

    I’m on parole and have been working out for years. I’ve been hitting it pretty hard since prison and have recently been released. I am thinking about taking no2 but would like to know if it will make me fail a piss test or not before I start taking it? Thanks

      Mike Jackson

      Mike Jackson

      June 3, 2016

      Re: does no2 affect urinary analysis tests?

      Generally, Nitric Oxide Supplements should not make you fail a drug test as it contains compounds that are already found in the body. However, it is recommended that you check the other ingredients of the product you take before use.


    June 12, 2016

    When does it actually start working?

    I have been taking it for 2 weeks and its not going anything. Does it actually work or is it a placebo?

      Mike Jackson

      Mike Jackson

      June 13, 2016

      Re: When does it actually start working?

      Results from Nitric Oxide supplements, like other bodybuilding supplements, vary from person to person. If you are taking the recommended serving size and are not experiencing effects such as enhanced vascularity, muscle strength, or improved blood circulation, the recommended amount may not be potent enough for your body. It may be time for you to try a different product.


    June 25, 2016

    Is Nitric Oxide OK for the aged?

    I am 83 yrs. old women, and I have lost my strength in my legs and arms. If I fall down I cannot get up without help. Will Nitric Oxide help me regain the strength in my arms and legs so I can at least lift my grandchild?
    I have slight high blood pressure, and take pills for it. also pills for cholesterol problem. Also have Neropothy because of Spinal Stenosis. Will it help with circulation in these areas. Please don’t tell me to ask my doctor, he is always very busy.

      Mike Jackson

      Mike Jackson

      June 27, 2016

      Re: Is Nitric Oxide OK for the aged?

      Studies have found that the use of Nitric Oxide for the elderly may help to reduce blood pressure, increase blood flow, and decrease symptoms of degenerative neurological disorders/diseases. However, studies regarding the interaction of Nitric Oxide with medications for high blood pressure, cholesterol, and other problems are very little if at all available. It is extremely important that careful attention is given to the possible negative interactions Nitric Oxide can cause in a person of your age. While asking your doctor may seem bothersome, it is highly recommended that you do as your doctor has a better understanding of your medical history and can safely advise you.


    August 1, 2016

    Can i take nitric oxide with carvedilol, lipitor and a low dose asprin regimen at the same time?

    Can i take nitric oxide with carvedilol, lipitor and a low dose asprin regimen at the same time?

      Mike Jackson

      Mike Jackson

      August 2, 2016

      Re: Can i take nitric oxide with carvedilol, lipitor and a low dose asprin regimen at the same time?

      It is highly recommended that you talk to your physician before adding any supplements to your intake of prescribed medications. While Nitric Oxide is a naturally produced by the body, additional Nitric Oxide consumption may negatively affect the potency of your prescribed medications.


    August 21, 2016

    L-Citruline and aspirin are they safe taken together?

    I have been taking a low dose – 750mg L-Citruline twice daily for two weeks. Have also been taking low dose aspirin long term. This morning I sneezed and nearly passed out, then felt light-headed and floaty for the remainder of the morning. Until this happened I have not experienced any other side effects. The low dose L-Citruline helps me to absorb more oxygen into my emphysema affected lungs.


    Den Tavares

    August 28, 2016

    Should I take Nitric Oxide first ?

    I will be starting training next week , however I would to know if it’s ok to the my Nitric Oxide Booster as a beginner?

      Mike Jackson

      Mike Jackson

      September 1, 2016

      Re: Should I take Nitric Oxide first ?

      A nitric oxide booster is okay to take as a beginner as long as you pay attention to the warnings on the label and follow the instructions. If you experience any negative side effects, it is highly recommended that you discontinue your use immediately.


    October 30, 2016

    Carnosine causing zinc deficiency

    After reading this article and the author claiming that there’s studies showing that high levels of carnosine and Histidine causing zinc imbalance and deficiencies I tried looking it up for myself online. I could not find a single article or research study talking about zinc deficiencies being a side effect. Can someone please debunk this for me or give me a link to the article talking about it.



    December 28, 2016

    Can i safely take NO with anabolic steroids?

    Can i safely take NO with anabolic steroid injections?


    EMan Mendoza

    January 4, 2017

    Dosage and Time

    Is it ok to take it (NO2 blast) after work out?



    April 27, 2017

    long term use and with cycling aleviate the side effects

    So, I typically workout every morning. I begin with N.O. Xplode (BSN) and Nitrix (BSN) pre-workout and BCAAs post-workout. I have been doing so for a little over a year. Always felt good and never had any real negative side effects. However, lately I have been noticing weaker erections and shorter performances. Could just be age related, but I have never had any similar symptoms before. So, I am wondering if it is supplement related. I have cycled off of all supplements and am hoping this will reverse itself.

    Any thoughts on NO supplements and erection strength? And if cycling can minimize effects?



    November 24, 2017

    17 year old taking pre workour supplements

    I’m 17 can i take pre-workout pills for muscle pumps with nitric oxide 3000mg



      February 13, 2018


      It can vary from supplement to supplement, but I think you’ll find that most supplements (especially NO supplements) will state that they’re formulated for individuals over the age of 18.


    December 14, 2017

    getting late to bed

    i’m 22 years old.i get to use NO explode suplement,when the very first day when i use it,my body get hotter plus i did not had a propper sleep,waking up every time.i need a good answer for it, how to reduce these.


    Richard Martinez

    October 5, 2019

    Richard Martinez

    Can NO cause extreme fatigue



    February 4, 2020


    I’ve taken “Sundown” brand of L-Arginine (500mg) per label instructions. May I continue to take this while also taking a supplement touted as a “Nitric Oxide” booster such as Ignite Labs N O 2?



      February 27, 2020


      Hey, Eddie. If you’re going to take multiple supplements that all increase NO, we’d suggest looking at the individual ingredients and summing up the total of each to determine whether or not you’re overdosing on any particular one. If you have any questions with regard to a specific ingredient in your NO booster, it would be best to ask a physician. Best of luck!

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