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2022's 10 Best
CDP Choline Supplements

Wouldn’t it be great if our body and immune system functioned like a Formula One engine? Allowing us to “step on it” whenever we needed to and letting us extract the absolute maximum in efficiency and performance, both mentally and physically?

Well, I’m sorry to have to break it to you, but… that isn’t the case. However, that hasn’t stopped us from tinkering with the human body’s vast intricacies in the hopes of crossing every possible mental and physical barrier.

This fascination has often compelled us to experiment with various substances, both natural and synthetic, in hopes of improving and prolonging our health. CDP choline (also known as citicoline) is one such nutrient. It has been in use in medical circles for quite a while now, mainly known for its cognitive benefits. And it just so happens that it has now found its way into our supplement stacks.

The purpose of this article is to educate and guide the average user and minimize any confusion there might be on this supplement. We will explore several facets, including CDP choline’s key benefits, how should you consume it, its side effects, and what to consider while buying and supplementing with it. Jump to Our 10 Best CDP Choline Supplement List


Understanding Choline


It is important to first understand what choline is. Individually, it’s a key nutrient that we require for normal bodily function. Choline plays an important role in ensuring healthy liver function, and a choline deficiency can actually damage the liver. For example, studies have shown that choline deficiency causes fatty deposits to accumulate in the liver.

Choline also helps with:

  • Decreasing inflammation
  • Maintaining a healthy nervous system
  • Proper muscle movement
  • Healthy metabolism & appetite suppression
  • Reducing the risk of breast cancer

CDP Choline & How It Works


It is important to understand the difference between “basic” choline and CDP choline. Basic choline comes in 2 forms: choline bitartrate and choline citrate. Both have various health benefits, but they don’t seem to have an impact on our cognitive health. Bummer.

CDP choline, however, has been shown to have a positive impact on several facets of cognitive health. Its cognitive benefits come from its ability to be converted to both choline and uridine, both of which can help with improving memory.

When CDP choline is taken orally, it releases two substances called cytidine and choline. Both play a crucial role in maintaining cognitive function. They are vital for the creation of phosphatidylcholine, a substance that plays a key role in the formation of the neuronal membrane surrounding neurons. This membrane facilitates smooth inter-cellular communication throughout our body.


Key Health Benefits of CDP Choline


SHARPER IQ & INTELLIGENCE

Myelin is a mixture of fats and proteins. It is critical for efficient neuron transmission, thus helping our intelligence. CDP choline helps with the regeneration and strengthening of myelin, as shown by a 2015 study.

During this animal study, an intentional weakening of myelin or “demyelination” was initiated through the use of specific drug. This led to a hampering of the motor coordination skills of the subjects. After the introduction of CDP choline, it was observed that the body facilitated an increase in oligodendrocytes and oligodendrocyte precursor cells. This led to the strengthening and regeneration of myelin, which led to a significantly restored level of motor skill coordination in the subjects.





IMPROVED MEMORY & ATTENTION SPAN

Acetylcholine is an important chemical that plays a critical role in healthy neural transmission. A 2018 study conducted on rats showed that CDP choline plays a crucial role in acetylcholine synthesis. A shortage of acetylcholine can severely compromise neural communication, thus impacting the entire immune system.

Moreover, a shortage of acetylcholine has shown to impact our cognitive ability negatively, such as our memory and attention span, as shown by this study. The study also shows that when CDP choline is administered orally or intravenously, it is very well absorbed and effective in combatting cognitive decline.

There are several studies that show that CDP choline helps with restoring acetylcholine levels, thus improving our memory, attention, and overall cognitive health. A 2012 study showed improved memory in adult women after CDP choline supplementation.

60 healthy adult women ages 40 to 60 were put through a clinical screening. Each subject was randomly assigned to three groups: a daily oral dose of 250 mg CDP, 500 mg CDP, or placebo for 28 days.

After 28 days of daily supplementation, the women were given a test measuring their attention and memory, and the women in 250 and 500 mg groups made far fewer mistakes and had better recall than the placebo group.

Another study showed that ensuring proper dosage of CDP choline during pregnancy can play a crucial role in ensuring long-term memory health in offspring.


IMPROVED COGNITIVE INDICATORS

A 2015 study showed how CDP choline brought about appreciable improvements in major cognitive indicators. The study was conducted with 24 healthy male subjects with the key objective to observe indicators such as processing speed, working memory, verbal learning, verbal memory, and executive function.

One group supplemented with 500 mg CDP choline daily, and the other group supplemented with 1000 mg. Both showed improvement in all the above-mentioned cognitive indicators.

AN EFFECTIVE ALZHEIMER’S TREATMENT

Alzheimer’s disease is an irreversible condition that slowly destroys neural connections and reduces brain tissue, thus severely damaging the ability to perform even basic tasks such as remembering names and driving.

CDP choline has proven to be an effective tool for Alzheimer’s treatment as shown by this 1999 study. There were 30 subjects aged between 65 and 73, all of them with Alzheimer’s symptoms. They were administered a CDP choline daily dose of 1000 mg. After a 12-week period, an increase in the percentage of brain bioelectrical activity was observed, as well as improved cognitive performance.

AN EFFECTIVE PARKINSON’S TREATMENT

This condition impacts our brain’s ability to control bodily movements, often affecting muscle rigidity and causing involuntary shivering and muscular jerks. CDP choline has shown to help in combating the condition’s progression.

A study conducted between 2012-14 highlights CDP choline’s role in combating Parkinson’s disease. The study was conducted with 185 Parkinson’s patients. They were randomly divided into a CDP treatment group and a control group.

Patients in the CDP treatment group received 200 mg citicoline sodium capsules orally three times daily in addition to their usual medication(s). They were re-evaluated after 12 and 18 months of treatment. The study concluded that CDP choline can delay the progression of cognitive impairment in sufferers of Parkinson’s disease.

BREAST CANCER PREVENTION

Breast cancer affects women all over the world, and choline may help prevent this type of cancer. A 2008 study was conducted with over 3000 women, half of which were given higher dietary choline. After the study, it was concluded that these women had a lower risk of developing breast cancer.

EFFECTIVE FOR SCHIZOPHRENIA SYMPTOM REDUCTION

Schizophrenia is a long-term mental condition involving a breakdown in the relation between thought, emotion, and behavior, leading to faulty perceptions and inappropriate actions.

A recent study was conducted with 73 schizophrenia patients. They were given 2500 mg of CDP choline daily for 8 weeks. The study found that CDP choline can improve the primary negative symptoms of schizophrenia. Jump to Our 10 Best CDP Choline Supplement List

APPETITE SUPPRESION

We all know that our fondness for untimely and unhealthy snacking is the reason we carry an extra tire around our waists. Although not strictly cognitive, appetite suppression is a noticeable benefit of CDP choline.

According to a trial conducted in 2010, a group of healthy individuals was supplemented with CDP choline for 6 weeks. They were given between 500 mg/day and 2000 mg/day. Although there weren’t any significant changes in their weight, the group that was on a 2000mg/day dose reported an appreciable decline in their appetite.

BRAIN TRAUMA TREATMENT

Brain trauma is one of the most threatening injuries that often brings about massive physical and psychological changes for the patient. The recovery process is often painfully slow.

Citicoline has shown to play a role in mitigating the impact of brain trauma. A 2014 meta-analysis involved more than 2700 brain trauma patients in 12 different clinical trials all studying the effect of citicoline in brain trauma treatment. The meta-analysis concludes:

“Citicoline should be considered as a valid approach to treat such patients in the countries where the drug is available.”

EFFECTIVE FOR SOME OPTICAL CONDITIONS

Glaucoma is a condition that is caused by increased nerve pressure behind our eyeballs. Starting with gradual weakening of sight, it can eventually lead to complete loss of sight in the affected eye.

Clinical studies have shown CDP choline to be an effective tool in reversing the condition. A 2005 study with 30 glaucoma patients had the objective to observe citicoline’s effect on retinal function and visual responses. The study lasted for 8 years, and the patients were given 1000/mg citicoline daily for two months, followed by a “drug-washout period”. After the study, substantial improvements were observed in retinal and cortical bioelectrical responses.




Side Effects


Many substances/supplements have side effects that may be compounded by certain conditions or medications. We strongly recommend consulting your doctor before incorporating citicoline into your daily use. Here are a couple of reported citicoline side effects:

• Supplementing with choline may cause diarrhea for some people

• Higher than usual choline levels may increase the risk of prostate cancer


Dosage


It is important to note that vegans are more likely to be choline deficient, since the usual choline-rich sources come from animals, such as: eggs, liver, fish, etc. Here’s how much choline should be taken daily:

• Adult men: 550 mg

• Adult women: 425 mg

• Pregnant women: 450 mg

• Nursing females: 550 mg


What to Consider While Shopping for Citicoline Supplements


There are plenty of options when it comes to buying supplements, and citicoline is no different. Here’s what you should look out for while buying your citicoline:

Dosage per serving. Different brands offer several per serving dosages ranging anywhere from 75 mg to all the way up to 500 mg per capsule. Consider your daily targeted dosage before settling on a label.

Proprietary blends. Quite a few supplements (including some citicoline brands) come with “proprietary blends” with precise dosages and daily values kept under wraps. That is not to say they are ineffective or intend to mislead. But if you want to have exact information on what you’re putting into your body, or if you’re taking it to treat a certain condition (and thus need a specific dosage), then it’s best to steer clear of proprietary blend options.

Customer reviews. You should find these on Amazon pages of each supplement and/or brand. They will give you a good idea of how good the brand is on their advertised claims.

Guarantee. Most reputable brands will stand by their quality and claims and will offer a money-back guarantee in case of unsatisfactory results.

Origin. It is advisable to stick to supplements made in the USA


Conclusion


Although not the sexiest of nutrients, such as the omega-3s or BCAAs, CDP choline has an important role in ensuring proper mental and physical health. You should make sure you’re not deficient in it, especially if you don’t typically consume a lot of animal meats and products.


Best CDP Choline Supplements


Our top 10 list of CDP choline supplements is organized to reflect what you most value in your supplements. First and foremost is quality. All of our top ten supplements meet high standards of quality and come from brands with a proven record in excellence and purity. Another important factor in deciding the top ten was cost. You don’t have to pay through the nose to get a high-quality CDP choline supplement. In addition, all the companies represented on our list have stellar records with customer service and prompt shipping. This ensures that your supplement experience is enjoyable from the first click to your final dose.

References

  1. Restorative Blends CDP-Choline and the Long-Term Benefits for Brain Health RestorativeBlends.com
  2. Steven H. Zeisel, M.D., Ph.D. and Kerry-Ann da Costa, Ph.D. Choline: An Essential Nutrient for Public Health PubMed.gov
  3. Xu, X., Gammon, M.D., Zeisel, S.H., Lee, Y.L., Wetmur, J.G., Teitelbaum, S.L., Bradshaw, P.T., Neugut, A.I., Santella, R.M., Chen, J. Choline Metabolism and Risk of Breast Cancer in a Population-Based Study. PubMed.gov
  4. Skripuletz, T., Manzel, A., Gropengießer, K., Schäfer, N., Gudi, V., Singh, V., Salinas Tejedor, L., Jörg, S., Hammer, A., Voss, E., Vulinovic, F., Degen, D., Wolf, R., Lee, D.H., Pul, R., Moharregh-Khiabani, D., Baumgärtner, W., Gold, R., Linker, R.A., Stangel, M. Pivotal Role of Choline Metabolites in Remyelination. PubMed.gov
  5. Gareri, P., Castagna, A., Cotroneo, A.M., Putignano, S., De Sarro, G., Bruni, A.C. The Role of Citicoline in Cognitive Impairment: Pharmacological Characteristics, Possible Advantages, and Doubts for an Old Drug with New Perspectives. PubMed.gov
  6. Erin McGlade, Allison Locatelli, Julia Hardy, Toshikazu Kamiya, Masahiko Morita, Koji Morishita, Yoichiro Sugimura, Deborah Yurgelun-Todd Improved Attentional Performance Following Citicoline Administration in Healthy Adult Women Scientific Research: An Academic Publisher
  7. Knott, V., de la Salle, S., Choueiry, J., Impey, D., Smith, D., Smith, M., Beaudry, E., Saghir, S., Ilivitsky, V., Labelle, A. Neurocognitive Effects of Acute Choline Supplementation in Low, Medium and High Performer Healthy Volunteers PubMed.gov
  8. Meck, W.H., Williams, C.L. Metabolic Imprinting of Choline by its Availability During Gestation: Implications for Memory and Attentional Processing Across the Lifespan PubMed.gov
  9. Meck, W.H., Williams, C.L. Double-blind Placebo-controlled Study with Citicoline in APOE Genotyped Alzheimer’s Disease Patients. Effects on Cognitive Performance, Brain Bioelectrical Activity and Cerebral Perfusion PubMed.gov
  10. Zhenguang Li, Pengfei Wang, Zhancai Yu, Hairong Sun, Jinbiao Zhang, Jiangshan Zhang, Yannan Cong, Chao Sun, Yong Zhang, Xiaohua Ju Effect of Citicoline Adjuvant Therapy on Mild Cognitive Impairment in Parkinson’s Disease International Journal of Clinical and Experimental Medicine
  11. Xu, X., Gammon, M.D., Zeisel, S.H., Lee, Y.L., Wetmur, J.G., Teitelbaum, S.L., Bradshaw, P.T., Neugut, A.I., Santella, R.M., Chen, J. Choline Metabolism and Risk of Breast Cancer in a Population-Based Study PubMed.gov
  12. Xu, X., Gammon, M.D., Zeisel, S.H., Lee, Y.L., Wetmur, J.G., Teitelbaum, S.L., Bradshaw, P.T., Neugut, A.I., Santella, R.M., Chen, J. Citicoline (CDP-choline) Add-on Therapy to Risperidone for Treatment of Negative Symptoms in Patients with Stable Schizophrenia: A Double-blind, Randomized Placebo-controlled Trial PubMed.gov
  13. Killgore, W.D., Ross, A.J., Kamiya, T., Kawada, Y., Renshaw, P.F., Yurgelun-Todd, D.A. Citicoline Affects Appetite and Cortico-Limbic Responses to Images of High-Calorie Foods. PubMed.gov
  14. Julio J. Secades Citicoline for the Treatment of Head Injury: A Systematic Review and Meta-analysis of Controlled Clinical Trials Journal of Trauma & Treatment

#1 - CDP Choline

Nutricost CDP Choline is our top choice, as it provides great value for the price. At 300 mg of citicoline per serving and 120 capsules per bottle, your CDP choline needs will be met for months.

Nutricost CDP choline helps to increase circulation to the brain and enhance cognitive function. It can also aid in recovery for those suffering from brain trauma.

• Serving size: 1 tablet

• 300 mg of citicoline per serving

• Vegan

• 120 capsules per container

• Non-GMO and gluten-free

• Third-party tested and made in the USA at an FDA approved facility

Keep Reading »

Nutricost CDP Choline is our top choice, as it provides great value for the price. At 300 mg of citicoline per serving and 120 capsules per bottle, your CDP choline needs will be met for months.

Nutricost CDP choline helps to increase circulation to the brain and enhance cognitive function. It can also aid in recovery for those suffering from brain trauma.

• Serving size: 1 tablet

• 300 mg of citicoline per serving

• Vegan

• 120 capsules per container

• Non-GMO and gluten-free

• Third-party tested and made in the USA at an FDA approved facility

Keep Reading »

#2 - EZ Melts Citicoline

EZ Melts Citicoline with Cognizin comes with 250 mg of citicoline per capsule. It facilitates the production of crucial neurotransmitters, and it prevents damage to healthy brain cells.

Moreover, it aids in maintaining normal levels of acetylcholine, which allows improvement in memory and learning ability. It is vegan and free of additives such as sugar.

• Serving size: 1 tablet

• 250 mg of citicoline per serving

• Vegan

• 60 chewable tablets per container

• Sugar and gluten-free

• Made in the USA

Keep Reading »

EZ Melts Citicoline with Cognizin comes with 250 mg of citicoline per capsule. It facilitates the production of crucial neurotransmitters, and it prevents damage to healthy brain cells.

Moreover, it aids in maintaining normal levels of acetylcholine, which allows improvement in memory and learning ability. It is vegan and free of additives such as sugar.

• Serving size: 1 tablet

• 250 mg of citicoline per serving

• Vegan

• 60 chewable tablets per container

• Sugar and gluten-free

• Made in the USA

Keep Reading »

#3 - Double Wood Supplements CDP Choline

Double Wood LLC’s CDP Choline supplement is a great value with each tablet providing 300 mg of CDP choline. It is great for sharpening your memory and recall, and it can improve mental energy, attention, and focus.

To top it off, they provide a 100% money-back guarantee.

• Serving size: 1 capsule

• 300 mg of citicoline per serving

• 60 capsules per container

• Made in the USA

• 100% money-back guarantee

Keep Reading »

Double Wood LLC’s CDP Choline supplement is a great value with each tablet providing 300 mg of CDP choline. It is great for sharpening your memory and recall, and it can improve mental energy, attention, and focus.

To top it off, they provide a 100% money-back guarantee.

• Serving size: 1 capsule

• 300 mg of citicoline per serving

• 60 capsules per container

• Made in the USA

• 100% money-back guarantee

Keep Reading »

#4 - TNVitamins Citicoline

If you find yourself choline deficient or need higher CDP dosages, then Total Nutrition’s TNVitamins Citicoline capsules are a great option, as each of these capsules provides 500 mg of citicoline at an affordable price.

Moreover, it is free of additives such as sugar, yeast, starch, wheat, sodium, gluten, etc.

• Serving size: 1 capsule

• 500 mg of citicoline per serving

• 30 capsules per container

• Free of additives such as sugar, yeast, starch, wheat, sodium, and gluten

Keep Reading »

If you find yourself choline deficient or need higher CDP dosages, then Total Nutrition’s TNVitamins Citicoline capsules are a great option, as each of these capsules provides 500 mg of citicoline at an affordable price.

Moreover, it is free of additives such as sugar, yeast, starch, wheat, sodium, gluten, etc.

• Serving size: 1 capsule

• 500 mg of citicoline per serving

• 30 capsules per container

• Free of additives such as sugar, yeast, starch, wheat, sodium, and gluten

Keep Reading »

#5 - Mindfully Nootropic Brain Booster

MINDFULLY Nootropic Brain Booster, distributed by WB Natural, is designed to facilitate efficient learning, improved memory, longer attention span, enhanced concentration, and stronger motivation.

It also aids in managing stress and anxiety and improving your mood. It is free of synthetics and added stimulants.

• Serving size: 1 to 2 capsules (depending on your needs)

• 200 mg or citicoline per serving

• 60 capsules per container

• Made in the USA

• 100% money-back guarantee

• Stimulant-free

Keep Reading »

MINDFULLY Nootropic Brain Booster, distributed by WB Natural, is designed to facilitate efficient learning, improved memory, longer attention span, enhanced concentration, and stronger motivation.

It also aids in managing stress and anxiety and improving your mood. It is free of synthetics and added stimulants.

• Serving size: 1 to 2 capsules (depending on your needs)

• 200 mg or citicoline per serving

• 60 capsules per container

• Made in the USA

• 100% money-back guarantee

• Stimulant-free

Keep Reading »

#6 - PeakNootropics Citicoline

Peak Nootropics Citicoline Sodium Capsules help with memory preservation and facilitates improved cognitive function by allowing increased blood flow to the brain.

It can help combat the effects of brain injury and aid in improving motor skills and mental concentration.

• Serving size: 1 capsule

• 200 mg of citicoline per serving

• 60 capsules per container

Keep Reading »

Peak Nootropics Citicoline Sodium Capsules help with memory preservation and facilitates improved cognitive function by allowing increased blood flow to the brain.

It can help combat the effects of brain injury and aid in improving motor skills and mental concentration.

• Serving size: 1 capsule

• 200 mg of citicoline per serving

• 60 capsules per container

Keep Reading »

#7 - MyoFuel Focus

MyoFuel Focus comes with a formula that has proven its efficacy in clinical trials. MyoFuel Focus aids in enhancing mental focus, attention, and concentration.

In addition to 250 mg of citicoline, it comes with 135 mg of caffeine per capsule that facilitates a spike in energy and attention span. Moreover, it brings about an improvement in memory, recall, and retention.

• Serving size: 2 capsules

• 250 mg of citicoline per serving

• 135 mg of caffeine per serving

• 60 capsules per container

• Made in the USA

Keep Reading »

MyoFuel Focus comes with a formula that has proven its efficacy in clinical trials. MyoFuel Focus aids in enhancing mental focus, attention, and concentration.

In addition to 250 mg of citicoline, it comes with 135 mg of caffeine per capsule that facilitates a spike in energy and attention span. Moreover, it brings about an improvement in memory, recall, and retention.

• Serving size: 2 capsules

• 250 mg of citicoline per serving

• 135 mg of caffeine per serving

• 60 capsules per container

• Made in the USA

Keep Reading »

#8 - Lumonol Prep

If you notice poor mood, anxiety, or weak concentration and focus in your child, then Lumonol Prep is a great choice. It comes with a combination of citicoline and 5 other nootropics such as L-theanine, magnesium, and rhodiola rosea.

All of these facilitate healthy brain function. Plus, it comes in orange-flavored chewable tabs that most children will easily take.

• Not for children under 8 years of age

• Serving size: 1 capsule

• 75 mg/serving Citicoline

• No added caffeine

• 30 capsules per container

• Made in the USA

Keep Reading »

If you notice poor mood, anxiety, or weak concentration and focus in your child, then Lumonol Prep is a great choice. It comes with a combination of citicoline and 5 other nootropics such as L-theanine, magnesium, and rhodiola rosea.

All of these facilitate healthy brain function. Plus, it comes in orange-flavored chewable tabs that most children will easily take.

• Not for children under 8 years of age

• Serving size: 1 capsule

• 75 mg/serving Citicoline

• No added caffeine

• 30 capsules per container

• Made in the USA

Keep Reading »

#9 - Redcross Wellness Citicoline

Dr. Ken Redcross Citicoline Elite Cognition Support comes with 250 mg of xerenoos citicoline, a form of citicoline with better effectiveness that has shown encouraging results in 95 clinical studies.

It helps in combating brain aging and facilitates improved memory and mood.

• Serving size: 1 capsule

• 250 mg of xerenoos citicoline per serving

• 60 capsules per container

Keep Reading »

Dr. Ken Redcross Citicoline Elite Cognition Support comes with 250 mg of xerenoos citicoline, a form of citicoline with better effectiveness that has shown encouraging results in 95 clinical studies.

It helps in combating brain aging and facilitates improved memory and mood.

• Serving size: 1 capsule

• 250 mg of xerenoos citicoline per serving

• 60 capsules per container

Keep Reading »

#10 - Purisure CDP Choline Powder

Purisure CDP Choline Powder (Citicoline Sodium) is great if you’re not a big fan of swallowing capsule after capsule. Since it comes in powder form, it is a bit easier to take.

But do make sure to measure your dosage (250 mg or 1/8 of a teaspoon). It is natural and stronger than basic bitartrate and citrate.

• Serving size: 250 mg or 1/8 of a teaspoon

• 250 mg of citicoline per serving

• 200 servings per pouch

• Natural

Keep Reading »

Purisure CDP Choline Powder (Citicoline Sodium) is great if you’re not a big fan of swallowing capsule after capsule. Since it comes in powder form, it is a bit easier to take.

But do make sure to measure your dosage (250 mg or 1/8 of a teaspoon). It is natural and stronger than basic bitartrate and citrate.

• Serving size: 250 mg or 1/8 of a teaspoon

• 250 mg of citicoline per serving

• 200 servings per pouch

• Natural

Keep Reading »

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