Agmatine is a neurotransmitter derived from L-arginine through a process called decarboxylation. Decarboxylation is a chemical reaction that removes a carboxyl group and releases carbon dioxide.
Agmatine is an analgesic, which means it blunts pain. This allows for an increased exercise intensity and endurance.
Agmatine also has several neuroprotective effects, such as overproduction of nitric oxide by inducible NO synthase. This has been tightly linked to neuroinflammation and neurodegeneration associated with ischemic injury.
Additionally, ongoing research shows agmatine contributes to the understanding of central nervous system disorders and the development of novel drug therapies.
An animal study revealed agmatine administration rapidly augments luteinizing hormone (LH) release in a dose-related fashion. Thus, agmatine stimulates testosterone production by increasing LH hormone in the pituitary gland, subsequently enhancing protein synthesis, strength, and muscle repair.
Also a powerful nitric oxide booster, agmatine relaxes blood vessels and inundates muscles with blood. This aids essential nutrient and oxygen delivery, facilitating better endurance and boosting growth hormone levels.
Agmatine also heightens insulin response, thanks to its peptides and metabolites which are responsible for glucose’s insulin-independent uptake during exercise. In turn, this leads to better glucose storage from carbohydrates.
Additional Agmatine benefits include:
Agmatine was shown to be safe, even in relatively high doses. Participants in a study received escalating regimens starting at 1.335 grams a day and ending with 3.560 grams a day for 21 days.
Some participants in studies with agmatine complained of gastrointestinal issues such as nausea and diarrhea.
If you are on any blood pressure medication, check with your doctor before supplementing with agmatine. Note agmatine did not antagonize the blood pressure reaction to the blood pressure reduction drug clonidine.
To take advantage of agmatine’s muscle growth and recovery benefits, experts recommend taking 500-1,000mg 30-60 minutes before workouts.
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