Professional Guide: HGH
May 20, 2013
Human growth hormone continues to be one of the most controversial topics in sports and in fitness today, but the truth about HGH remains a mystery for most people. In this comprehensive HGH guide, we intend to help you get a better understanding about HGH and how to safely increase HGH levels.
In this guide, you’ll find information about how HGH is naturally produced in your body, the benefits of increasing HGH, ways to safely and legally increase HGH levels, the differences between HGH injections and HGH supplements, HGH myths and more.
- 1. Introduction
- 2. Understanding HGH
- 3. Clinically Proven HGH Benefits: What the Studies Show
- 4. Increasing HGH
- 5. HGH Medications
- 6. HGH Dietary Supplements: HGH Secretagogues and Releasers
- 7. Natural Ways to Boost HGH
- 8. HGH Myths and Misconceptions
Human growth hormone is a peptide hormone created naturally by the body and plays a key role in overall health and development. HGH is the primary hormone responsible for growth stimulation, cell reproduction and cell regeneration in both men and women.
HGH is produced by the pituitary gland and initiates growth and physical development in children and adolescents. HGH is also a key to regulating body composition, body fluids, and bone growth, sugar and fat metabolism and possibly heart function.
But What Is HGH?
Human Growth Hormone, also called somatotropin*, is an anabolic 191-amino acid, single-chain polypeptide synthesized, stored, and released by somatotroph cells in the anterior lobe of the pituitary gland.
Photo Credit: Wikipedia.org
Once secreted, it commands various functions in the body including tissue repair, cell regeneration and reproduction, calcium retention, lipolysis, and enzyme performance.
*Somatotropin is often confused with somatropin. Despite the similarity in their names, these two hormones are very different. Somatrotpin is the natural form of human growth hormone. Somatropin, on the other hand, is biosynthetically prepared and doesn’t occur naturally. It is engineered to mimic human growth hormone.
HGH’s Role in the Body
Hormones are chemical messengers that circulate throughout the bloodstream and provide instruction to specific cells based on their functions.
Think of a hormone like a limo driver holding a sign at an airport. Most people (or in this case, cells) pass by and ignore the driver (hormone) because they have specific places to go. However, when the right one comes along, the cells read the sign and follows the hormone’s instructions. The two work together, one driving the other into action.
Human growth hormone is essentially holding the sign that instructs cells to grow. By adolescence, HGH production significantly rises, resulting in an increase in bone density, muscle mass and healthy growth.
HGH production is typically at its peak between ages 21-30, ensuring the body reaches its full growth potential. After reaching its peak around age 30, HGH production is gradually reduced by about 14% every 10 years, but secretion will continue for the remainder of one’s life.  HGH is responsible for maintaining a wide variety of functions within the body:
- HGH signals the liver and other tissues in the body to secrete insulin growth factor-1( IGF-1). This chemical boosts chondrocyte (cartilage cell) production for improved bone and muscle growth.  HGH also causes differentiation and proliferation of myoblasts (muscle cells).  And HGH regulates amino acid uptake and protein synthesis for building muscle tissue. 
- Protein, Fat and Carbohydrate Metabolism – It triggers and encourages protein anabolism (building). It increases amino acid uptake, enhances protein synthesis, and reduces protein oxidation (loss of electrons). HGH enhances fat utilization by stimulating triglyceride breakdown and oxidation in adipocytes (fat cells).  HGH also maintains blood glucose levels and is said to have an “anti-insulin” effect. 
Clinically Proven HGH Benefits: What the Studies Show. . .
HGH is clinically proven to provide numerous health benefits, and maximizing its production can help you in the following ways:
HGH for Weight Loss
In a groundbreaking study conducted by Daniel Rudman, MD, researchers observed HGH’s amazing effect on weight loss. The study involved 21 healthy men aged 61 to 81.
At the end of the treatment, participants experienced an 8.8 % increase in lean body mass and a 14.4% decrease in adipose-tissue mass. 
Researchers concluded, “Diminished secretion of growth hormone is responsible in part for the decrease of lean body mass, the expansion of adipose-tissue mass, and the thinning of the skin that occur in old age.”
HGH for Muscle Building
As its name implies, human growth hormone is primarily responsible for growth. This includes the growth and maintenance of healthy bones, joints, and muscle tissue. In a study involving more than 300 participants, researchers observed the physiological effects of HGH compared to a placebo. Those who received growth hormone experienced an increase in lean body mass and muscle growth. 
HGH for Anti-Aging
While HGH’s anti-aging abilities are often exaggerated by supplement manufacturers and product advertisements, this hormone does have the potential to fight the signs of aging.
In a revolutionary HGH study, researchers observed HGH had a positive effect on more than just muscle and body fat. Those who received HGH therapy also experienced a significant improvement in mood, blood pressure, blood sugar, and skin elasticity. Furthermore, organs (such as the heart and kidney) returned to normal size (vital organs tend to shrink with age). 
HGH for Cholesterol, Blood Pressure and Heart Health
HGH improves various factors contributing to cardiovascular failure and heart disease. Studies show HGH significantly reduces cardiovascular health risks and optimizes overall heart health.
In an Oxford study, individuals who received HGH replacement therapy experienced an improvement in total cholesterol, HDL cholesterol, and LDL cholesterol in less than 6 months. 
In a separate study, growth hormone treatment increased mRNA levels of the vascular smooth muscle KATP channel. Scientists found GH treatment decreases systolic blood pressure and increases cardiac output. 
HGH for Sleep
Interestingly enough, sleep is just as dependent on HGH as HGH is on sleep. Researchers discovered growth hormone deficient young adults often experienced a significant decrease in delta sleep time (stages 3 and 4). To compensate, the total sleep time was significantly increased compared to age- and sex matched normal subjects. 
An additional study examined HGH’s effects on pulmonary function and sleep quality in children with Prader-Willi syndrome. After 12 months, “GH intervention improved body composition and REE and may contribute to better sleep quality.”
HGH for Mood and Mental Health
Many HGH users have exclaimed that HGH helps them feel decades younger while improving their mood and enhancing their memory.
As it turns out, HGH raises neurotransmitter B-endorphin levels, which acts much like an antidepressant. Furthermore, HGH lowers dopamine, which is often associated with agitation and stress.
In 1989, researchers studied HGH patients’ quality of life both before and after HGH treatment. “Significant psychological improvement was noted in the HGH-treated patients’ perception of their energy and mood compared to the placebo group.” 
HGH deficiency often results in negative side effects such depression, fatigue, and short-term memory. Fortunately, HGH therapy may counter this effect.
After a year of treatment, participants who were given HGH experienced a “normalization of memory functioning.” Researchers concluded, “GH replacement improves memory function in adults with Co-GHD (childhood-onset growth hormone deficiency.” 
Furthermore, a separate study revealed increased HGH improved cerebral blood flow and increased microvascular density. “By increasing IGF-1 production, HGH may improve spatial working and reference memory.” 
HGH for Immunity
Studies conducted by Dr. Keith Kelley (and others) show HGH improves the immune system by:
- Manufacturing antibodies
- Stimulating bacteria-fighting macrophages
- Increases T-Cell and Interleukin2 production
- Promoting red and white blood cell production 
“Neuroendocrine protein hormones (such as HGH) influence immunity,” Dr. Kelley explains. “New findings highlight a previously undiscovered route of communication between the immune and endocrine systems that is now known to occur at the cellular level. This communication system is activated when inflammatory processes induced by proinflammatory cytokines antagonize the function of a variety of hormones, which then causes endocrine resistance in both the periphery and brain.” 
HGH for Bone Density
While HGH is commonly used to increase bone density and promote bone growth in children, many experts agree HGH has a positive impact on bone health in adults as well.
“GH plays an important role in maintaining the integrity of the adult skeleton,” points out British researchers,”[though] the physiological role of GH in the adult skeleton in unknown.” 
In a 1993 study, researchers observed a significant improvement in bone mineral content in subjects who received HGH treatment for 6 months. 
HGH for Sexual Performance and Libido
In a recent article published by ABC News, individuals who received legally prescribed HGH experienced significant improvements in skin and a “spiced-up sex life.” 
According to Dr. Ronald Klatz, author of Grow Young with HGH, “[HGH] may be the most powerful aphrodisiac ever discovered, reviving flagging sexual and potency in older men.” 
While clinical research on HGH’s libido-boosting effects is limited, there are plenty of studies verifying HGH’s ability to increase energy and stamina, decrease fatty tissue, as well as an improve mood and mental health. All of these benefits contribute to improved sexual performance and function.
Furthermore, HGH is known to affect IGF-1 levels, a hormone which influences testosterone production. Studies on IGF-1 demonstrate a direct impact on sex hormones and sex organs.
According to researchers, IGF-1 therapy resulted in a “progressive rise in luteinizing hormone, follicle-stimulating hormone and testosterone. Concomitantly, there was an increase in size of the testes and penile length.” 
In a separate study, researchers examined the effect of human growth hormone on erections. “We believe our date provide strong evidence that GH may be of major importance in the maintenance of male erectile capability-probably through a stimulating effect on cyclic guanosine monophosphate generate in human cavernous smooth muscle – and that a decline in GH release may contribute to the manifestation of erectile dysfunction.” 
While both studies focused primarily men, it would be easy to assume HGH could have a significant impact on sexual performance in both sexes.
HGH for Hair Loss
Clinical research on HGH for hair loss is limited, but promising. In a 1996 study, researchers observed HGH’s effects on intermediate-sized follicles triggered by atresia.
Researchers observed, “The total population of follicles was significantly greater in the GH-treated group than in the control, and the difference was attributed to the increase in the number of large follicles more than 500 micrograms.” 
Further human trials still need to be conducted in order to confirm this effect, but so far, many HGH users report an improvement in the health and overall growth rate of their hair as an unexpected benefit.
Understanding HGH Medications
Although scientists had known about HGH since the early 1920s, it wasn’t isolated until 1956. Not long after, many doctors began to use HGH to treat children suffering from stunted growth and other developmental problems. 
During its earlier stages, HGH treatments were fairly conservative due to short supply. Before scientists could recreate it synthetically, the hormone had to be extracted from human cadavers to be used in medications. 
In 1985 the US Food and Drug Administration put an end to the distribution of cadaver-derived HGH due to drugs being contaminated by Creutzfeldt-Jakob Disease (CJD). CJD is similar to mad cow disease or accelerated Alzheimer’s, which causes rapid brain degeneration and death within a year of the first symptoms. It can lie dormant for decades after exposure, and there is no treatment or test for CJD. 
In response, biotechnology company Genentech and drug company Eli Lilly independently began working on a new way to manufacturer HGH through recombinant bacteria.
To create synthetic HGH, researchers inserted gene coding into genetically modified bacteria. “This genetic transformation turned the bacteria into little factories to pump out HGH, leading to a limitless source of pure HGH with little risk of contamination,” explains the National Museum of American History.
Six months after the FDA banned cadaver-derived HGH, the FDA approved Genentech’s recombinant HGH Protropin.
Since then, advances in technology have enabled manufacturers to release various types of synthetic HGH medications.
The synthetic HGH is then injected into the bloodstream where it mimics the effects of naturally produced HGH.
Acquiring an HGH Prescription
Even with so many manufacturers developing synthetic HGH medications, HGH medications are only available legally through a prescription most frequently for children but more and more for adults suffering with growth hormone deficiencies.
Synthetic HGH is approved by the FDA for specific uses including:
- Hormonal deficiency that causes short stature in children
- Long-term growth failure treatment due to lack of exogenous GH secretion
- Long-term treatment of short stature associated with Turner syndrome
- Adult short bowel syndrome
- Adult deficiency due to rare pituitary tumors or their treatment
- Muscle-wasting disease associated with HIV/AIDS 
Any other HGH use is prohibited by law.
“The Secretary of HHS has not authorized, for example, any HGH use for anti-aging,
bodybuilding, or athletic enhancement.” 
Before prescribing synthetic HGH injections, your doctor must first analyze HGH levels and determine whether or not they fall under a healthy range.What’s a Normal Range?
HGH levels vary greatly between individuals at different times of day, so your doctor will evaluate your results based on your health and other factors.
The following numbers may be used as a general guide:
- For men: less than 5 nanograms per milliliter (ng/mL)
- For women: less than 10 ng/mL
- For children: less than 20 ng/mL
HGH Injections: Side Effects and Safety Concerns
HGH can lead to side effects if left unregulated. Side effects may range from minor body alterations that can be corrected through simple treatments to major life threatening and permanent complications.
The following are just a few examples of conditions triggered by increasing HGH:
- Joint pain and swelling: HGH increases chondrocyte production which triggers cartilage growth. Too much HGH may result in localized swelling and joint edema as well as chronic inflammation and arthritis.
- Carpal tunnel syndrome: Carpal tunnel is a painful wrist and finger joint condition which often results in joint numbness and pain. Elderly men treated with HGH are more likely to experience carpal tunnel
- Elevated blood pressure: HGH stimulates renin-angiotensin-aldosterone system (RAAS) and lithium clearance. RAAS regulates blood pressure, and when activated it increases blood pressure and triggers hypertension 
- Increased susceptibility to diabetes: HGH acts on liver cells to stimulate the production of IGF-1. High IGF-1 levels decrease insulin uptake and subsequently lower HGH production. Some sources report HGH therapy results in hypoglycemia while others suggest the early onset of diabetes. 
- Tumors: HGH stimulates growth, and this includes the growth of unwanted and potentially dangerous cells. New research suggests HGH injections may be linked to colon cancer and Hodgkin’s disease. 
- Gynaecomastia (in men): Gynaecomastia is the development of abnormally large mammary glands in men. Elderly men with low IGF-1 were more likely to experience gynaecomastia due to “the effects of the hormone expanding lean body mass and redoing adipose mass.” 
Consequently, with so many risks involved, doctors are required to closely monitor HGH levels in patients using synthetic HGH.
HGH Dietary Supplements: HGH Secretagogues and Releasers
HGH injections are the most reliable method for increasing HGH levels. However, not everyone qualifies to receive an HGH treatment, and the potential risks may outweigh the benefits if used incorrectly.
Because of the benefits available through increasing HGH, multiple nutritional supplement manufacturers have developed HGH supplements. These supplements most often fall in to two different categories, secretagogue or releaser, but are generally made with amino acids, vitamins, minerals and herbal extracts.
What Is an HGH Secretagogue?
According to Dr. Lam, MD., “a secretagogue (pronounced se-cre-ta-gog) is a natural polyamino acid chain that is postulated to initiate the pituitary gland to release growth hormone.” Whereas synthetic HGH injections trick the body into thinking it has produced HGH, HGH secretagogues interact with the pituitary gland to enhance the body’s ability to produce more HGH naturally. Essentially, one mimics HGH, the other triggers its release.
A secretagogue can consist of agents biologically natural to the body, an ingested compound found in plants, or synthetic compounds created in a laboratory. 
A biologically natural secretagogue, for example, would be ghrelin. Ghrelin is a naturally produced peptide that triggers HGH release. It is created by the hypothalamus and stimulates the anterior pituitary gland to boost HGH production. 
Secretagogoue’s often are differentiated from HGH releasers because they contain synthetic HGH in small, almost untraceable, amounts.
What Is an HGH Releaser?
An HGH Releaser, on the other hand, is much like an HGH secretagogue in that it triggers HGH secretion. However, HGH releasers are completely natural rather than created synthetically in a lab.
HGH releasers often consist of amino acids, vitamins, and minerals which improve thyroid and pituitary function as well as optimize overall health and wellbeing. This creates the ideal environment for HGH to be produced more abundantly.
Popular HGH Releasing Ingredients:
- L-Arginine – Arginine suppresses somatostatin (GHIH) secretion and increases resting growth hormone levels by as much as 100% 
- L-Lysine – When combined with arginine, lysine increases somatotropin and insulin release. 
- L-Ornithine – Ornithine hydrochloride increases HGH levels when combined with strength training.  When combined with carnitine, ornithine optimizes nighttime HGH secretion. 
- L-Glutamine – Oral glutamine increases HGH production within 90 minutes of ingestion. 
Restingly, many amino acid HGH releasers are only effective when used in high dosages or in combination with each other. When looking for an HGH releaser, it is important to find one with clinically proven concentrations and combinations of proven HGH releasing ingredients.
Are HGH Secretagogues and Releasers Safe to Use?
HGH secretagogues may or may contain very minimal amounts of synthetic HGH and releasers do not contain real or synthetic human growth hormone in any amount, so you don’t have to worry about the side effects and risks associated with HGH medications.
Typically releasers are safe to use on a regular basis because HGH releasers work naturally with your body to optimize HGH production and contain only natural HGH ingredients.
Although HGH releasers contain all-natural ingredients, this does not guarantee every product is safe. HGH-releasing supplements, unlike synthetic HGH, do not require careful monitoring by a physician or FDA-approval.
While this availability is more convenient for some, it also makes it difficult to find a product that is both safe and effective. Some manufacturers use ingredients in concentrations too high to be truly considered safe. On the other hand, some manufacturers include just enough amino acids to look good on the label but not enough to be effective.
According to the Office of Dietary Supplements:
“Dietary supplements are complex products. The FDA has established quality standards for dietary supplements to help ensure their identity, purity, strength, and composition . . . while the supplement company is responsible for having evidence that their products are safe and the label claims are truthful and not misleading, they do not have to provide that evidence to the FDA before the product is marketed.” 
Consequently, it is up to the consumer to carefully read the ingredient label and double-check the ingredients are safe. Take special care with proprietary blends, as you never know what’s exactly inside.
When in doubt, consult your doctor to determine if an HGH releasing product is right for you.
Are HGH Secretagogues and Releasers Legal?
So long as an HGH secretagogue does not contain synthetic HGH (or any other controlled substance), then it is legal to buy and use without a prescription. Whether your a organization allows the use of HGH-enhancing supplements is a different matter entirely.
Many athletes and bodybuilders turn to HGH in order to improve body composition and muscle mass. Since synthetic HGH is difficult to obtain legally, many more athletes turn to HGH releasers for an extra boost in physical performance.
While HGH releasers are legal, specific ingredients in an HGH releaser may be banned by certain sports organizations and athletic competitions.
How to Use HGH Dietary Supplements
Recommended usage varies depending on the product and ingredients included however, the following provides looses guideline, but as always, best results come from following manufacturer directions carefully and using dosages recommended by an expert.
- Oral sprays often contain a mild homeopathic HGH formulation.***
- To use an HGH spray, shake the bottle thoroughly. Spray two or three times under the tongue at least 30 minutes after eating.
- Hold the liquid under the tongue for at east 20 seconds without swallowing to enable absorption in the lining of the mouth (oral mucosa).
- After 20 seconds, swallow remaining HGH.
- HGH drops, much like oral sprays, are also absorbed in oral mucosa. Depending on the recommended dosage, place multiple drops under the tongue up to three times daily.
- Allow the product to absorb for at least 30 seconds to 1 minute before swallowing, and do not eat for at least 30 minutes prior to use.
- For best results, take the drops in the morning, before a workout, or a few hours before bedtime.
- HGH supplement dosing varies widely. Some products offer great results with a single capsule per day, while others require up to 6 or more capsules per day.
- Take HGH supplements with at least 8 to 16 oz. of water.
- Some supplements recommend taking food to reduce stomach upset, while others suggest avoiding it to optimize absorption.
- Read the label carefully.
For enhanced results, exercise regularly, eat a well-balanced diet, and get plenty of sleep. ***FDA Warning: “All firms which manufacture, prepare, propagate, compound, or otherwise process homeopathic drugs must register as drug establishments in conformance with Section 510 of the Act and 21 CFR207.” 
Although homeopathic HGH is regulated differently than supplements, it is still required to meet FDA rules and regulations. Many manufacturers try to sell illicit HGH claiming it to be “homeopathic” without meeting FDA standards.
When to Expect Results Using HGH Supplements
Everyone responds differently to HGH releasers and secretagogues, much like everyone responds differently to HGH injections.
Because HGH sprays contain much lower HGH concentrations, it may take weeks or even months before consumers experience any positive results.
Similarly, HGH supplements contain ingredients designed to stimulate HGH production without the actual hormone. While these ingredients may boost HGH levels temporarily, it may take a while before the pituitary gland responds to the treatment.
Furthermore, many HGH supplements contain additional ingredients to increase energy and improve performance. It’s possible the positive effects experienced by the user are a result of these ingredients rather than an increase in HGH production.
Natural Ways to Boost HGH
There are certain dietary and habit changes individuals can make to enhance HGH production without using a medication or even a dietary supplement.
Get Adequate Sleep
HGH is secreted in spurts throughout the day. However, its largest and most predictable pulse occurs during sleep.
There are five sleep stages:
- Stage 1: Relatively light stage of sleep. During this stage, the brain produces high amplitude theta waves, which are very slow brain waves. This period lasts a brief 5-10 minutes.
- Stage 2: Also a light sleep stage. The brain produces bursts of rapid, rhythmic activity known as sleep spindles. Body temperature and heart rate slows. This period lasts approximately 20 minutes.
- Stage 3: A deep sleep. The brain produces delta waves. It is a transitional stage between a light sleep and a very deep sleep.
- Stage 4: A deep sleep lasting approximately 30 minutes. The brain emits delta waves. Both stages 3 and 4 are considered the most restorative stages.
- Stage 5: REM Sleep. This stage is characterized by rapid eye movement, respiration, and increased brain activity. During the stage, the brain and other body systems become more active, though muscles become more relaxed.
According to an investigative study, researchers observed plasma hormone levels during the various sleep stages. If normal sleep patterns were interrupted, resulting in sleep deprivation, GH secretion was prolonged. 
Researchers concluded, “The nocturnal growth hormone surge is largely sleep-dependent; temporal associations between GH and SWS (slow wave sleep) are not reliable after sleep deprivation.” 
Pay Attention to Nutrition
You’ve probably heard the phrase, “you are what you eat?”
Without amino acids, vitamins, minerals, and other nutrients, your body will unable to perform at its peak, and subsequently, HGH production will suffer.
Carbohydrate-rich foods increase blood sugar levels. The pancreas then secretes insulin into the bloodstream to shuttle the sugar to various body tissues where it is then converted into useable energy.
However, insulin and growth hormone work antagonistically, each one inhibiting the other’s effects. The more insulin you have, the less HGH is able to function and vice versa. 
According to James Jamieson and Dr. L.E. Dorman, “Growth hormone levels increase significantly when insulin levels are low, about four hours after a meal . . .But remember, the largest burst of GH is released during the early hours of sleep- hence, our eating habits are crucial to maximizing this nighttime secretion. By avoiding food during the last four hours before bedtime we may enhance circadian growth hormone release, and fat burning potential.” 
Consequently, to optimize HGH production, it’s best to consume a diet low in carbs. While you should not completely eliminate carbohydrates from your diet, choose foods that breakdown slowly and are low on the glycemic index.
“Avoiding refined flours and simple carbohydrates helps to control insulin thereby optimizing GH secretion,” explains Jamieson. “For instance, a breakfast that includes steel cut oats will offer more a more sustained glucose supply because they are higher in fiber than rolled oats. Adding raw ground flaxseeds supplies even more fiber along with beneficial omega-3 fatty acids which work to slow down the uptake of glucose into the bloodstream. Whole grains contain more fiber and are always a better choice than refined grains. These guidelines apply to snacks and meals throughout the day.” 
Furthermore, experts recommend avoiding alcohol while supplementing with HGH. Alcohol has little nutritional value and is relatively high in calories. Consequently, the body treats alcohol as fat, breaking down the sugars into fatty acids.
Due to HGH’s anti-insulin effects, HGH inhibits the liver’s ability to break down and eliminate alcohol.
“Alcohol, in any appreciable quantity, blunts the HGH-releasing effect of amino acids and also suppresses natural HGH release,” says Jerry Emanuelson, science writer for Futurescience, LLC . “An ounce or less of alcohol two or three hours before taking a HGH releaser will have little effect on HGH release, but using alcohol to get to sleep can dramatically suppress your natural HGH release during sleep.” 
Alcohol decreases sleep duration and increases wakefulness.
In addition to avoiding high-carb foods and alcohol, it’s important to eat a well-balanced diet consisting of fruits, vegetables, protein, healthy fats, and fiber.
Certain foods also contain HGH-boosting amino acids, creating the ideal environment for its production. While the concentrations won’t be as high as the amino acids found in HGH releasing supplements, consuming the following foods may optimize HGH production.
Foods High in L-Arginine:
- Sesame seeds, sunflower seeds, and nuts
- Soy protein isolate
- Chocolate, popcorn, and carob
- Brown rice, oatmeal, and whole wheat bread
- Gelatin desserts
Foods High in L-Ornithine (can also be produced from arginine):
- Chicken, fish, and meat
- Dairy products
- Beans and legumes
Foods High in L-Lysine:
- Protein-rich foods such as red meat, pork, and poultry
- Cod and sardines
Foods High in L-Glutamine (Glutamine is synthesized from glutamate):
- Protein-rich foods such as beef, chicken, fish, and beans
- Dairy products such as cheese and yogurts
- Spinach and parsley
Participate in Intensive Exercise
Although food and sleep create the ideal environment for HGH production, exercise is proven to increase HGH secretion.
According to researchers, “the exercise-induced growth hormone response (EIGR) is well recognized and although the exact mechanisms remain elusive, a number of candidates have been implicated. “ 
“Resistance training results in a significant EIGR,” explains researchers. “Evidence suggests that load and frequency are determining factors in the regulation of HGH secretion.”  Endurance Training:
“The EIGR to endurance exercise is associated with intensity, duration, frequency, and mode of endurance exercise. A number of studies have suggested an intensity ‘threshold’ exists for EIGR. An exercise intensity above lactate threshold and for a minimum of 10 minutes appears to elicit the greatest stimulus to the secretion of HGH .“
But what is the lactate threshold?
The lactate threshold is the exercise intensity at which lactate acid starts to accumulate in the blood stream due to the body’s inability to buffer it.
Lactic acid is a byproduct of the body’s energy production processes. When oxygen is limited, the body converts pyruvate into lactic acid, which increases glucose breakdown and energy production.
However, the acid is then split into lactate and hydrogen. The hydrogen ion interferes with electrical signals in muscles and nerves, which in turn slows energy reactions and impairs muscle contractions. The longer you exercise, the more hydrogen builds up in the blood stream, resulting in muscle fatigue and that “burning” sensation associated with intensive exercise.
Although the exact mechanisms behind HGH secretion and lactate thresholds are still being studied, the preliminary research is promising.
“Exercise training above the lactate threshold may amplify the pulsatile release of HGH at rest, increasing 24-hour HGH secretion.” 
By striking a balance between exercise, nutrition, and sleep, you can significantly increase natural HGH production.
HGH Myths and Misconceptions
There is a lot of hype and rumor circulating about HGH. Finding the facts isn’t always as easy as it seems.
To eliminate confusion, the most common myths and misconceptions are listed below:
Myth 1: HGH Is a Steroid
Although many athletes, body builders, and fitness enthusiasts abuse HGH injections and combine HGH with additional steroids, HGH itself is NOT a steroid.
Steroids consist of male-oriented hormones such as testosterone which have a significant impact on muscle mass and physical performance.
Myth 2: HGH Will Bulk You Up
While HGH encourages muscle growth, promotes protein synthesis, and optimizes lean muscle mass, it is not an effective performance enhancer when used alone.
HGH essentially creates the ideal environment for muscle growth, but how you use that boost in energy is up to you. In order to see the growth offered by increasing HGH levels, individuals must combine a balanced, healthy diet with regular weight and resistance training.
Myth 3: HGH Is Illegal
HGH is legal and approved by the FDA for specific medical conditions. However, HGH is illegal without a prescription.
HGH releasers, however, do not contain HGH and are completely legal to use on a regular basis.
Myth 4: HGH Is Dangerous
HGH can wreak havoc on the body when left unregulated, and there are numerous studies to show its potential for causing negative side effects when not used safely.
However, HGH medications also provide numerous benefits as well, and when carefully monitored by a doctor, the benefits often outweigh the risks.
HGH releasers are also an extremely safe way to safely increase your HGH levels.
Myth 5: HGH Causes Rapid Weight Loss
Individuals with low HGH often experience fatigue, a decrease in lean muscle mass, and an increase in body fat. When HGH levels are restored to a healthy range, the effects are reversed and many lose a few extra pounds but it can take time to burn fat and lose a significant amount of fat.
HGH is not a miracle weight loss supplement and any changes in weight or body composition are miniscule when compared to the benefits of a healthy diet and regular exercise.
Myth 6: All HGH Supplements are FDA Approved
HGH medications are only approved by the FDA when they have been produced in an FDA-supported facility and distributed to treat a medical condition.
HGH sprays, drops, releasers and dietary supplements do not follow the same rules and regulations as prescription HGH, and do not require FDA approval before being released on the market.
 Reynolds, Gretchen. “Raging Hormones.” New York Times. Aug 20, 2006. Available from: http://www.nytimes.com/2006/08/20/sports/playmagazine/20hgh.html?_r=0
”Human Growth Hormone (HGH).” WebMD. Available from: http://www.webmd.com/fitness-exercise/human-growth-hormone-hgh
 Natelson BH, Holaday J, Meyerhoff J, Stokes PE (August 1975). “Temporal changes in growth hormone, cortisol, and glucose: relation to light onset and behavior”. Am. J. Physiol. 229 (2): 409–15. PMID 808970.
Powers M (2005). “Performance-Enhancing Drugs”. In Leaver-Dunn D, Houglum J, Harrelson GL. Principles of Pharmacology for Athletic Trainers. Slack Incorporated. pp. 331–332. ISBN 1-55642-594-5
 Emanuelson, jerry. “Human Growth Hormone.” Life Extension Manual. 2002-2012. Chapter 5. Available from: http://www.futurescience.com/hgh.html
 Bowen, R. “Growth Hormone (Somatotropin).” The Hypothalamus and Pituitary Gland. Colorado State University. Dec 2006. Available from: http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/hypopit/gh.html
 Neoklis A. Georgopoulos, Kostas B. Markou, Anastasia Theodoropoulou, George A. Vagenakis, Panagiotis Mylonas, Apostolos G. Vagenakis. “Growth, pubertal development, skeletal maturation and bone mass acquisition in athletes.” HORMONES 2004, 3(4):233-243. Available from: http://www.hormones.gr/110/article/article.html
 J J Cook, K M Haynes and G A Werther. “Mitogenic effects of growth hormone in cultured human fibroblasts. Evidence for action via local insulin-like growth factor I production.” J Clin Invest. 1988;81(1):206–212. doi:10.1172/JCI113296. Available from: http://www.jci.org/articles/view/113296
 Schambelan M, Mulligan K, Grunfeld C, Daar ES, LaMarca A, Kotler DP, Wang J, Bozzette SA, Breitmeyer JB. “Recombinant human growth hormone in patients with HIV-associated wasting. A randomized, placebo-controlled trial. Serostim Study Group.” Ann Intern Med. 1996 Dec 1;125(11):873-82. Available from: http://www.ncbi.nlm.nih.gov/pubmed/8967667
 Daniel Rudman, M.D., Axel G. Feller, M.D., Hoskote S. Nagraj, M.D., Gregory A. Gergans, M.D., Pardee Y. Lalitha, M.D., Allen F. Goldberg, D.D.S., Robert A. Schlenker, Ph.D., Lester Cohn, M.D., Inge W. Rudman, B.S., and Dale E. Mattson, Ph.D. “Effects of Human Growth Hormone in Men over 60 Years Old.” The new England Journal of Medicine. 1990; 323:1-6July 5, 1990DOI: 10.1056/NEJM199007053230101 Available from: http://www.nejm.org/doi/full/10.1056/NEJM199007053230101
 James Howenstine MD. A Physicians Guide To Natural Health Products That Work. page 233
 Takahashi Y, Kipnis D, Daughaday W. “Growth hormone secretion during sleep”. J Clin Invest 1968. 47 (9): 2079–90. doi:10.1172/JCI105893. PMC 297368. PMID 5675428. Available from: http://www.ncbi.nlm.nih.gov/pubmed/5675428
 Mehta A, Hindmarsh PC . “The use of somatropin (recombinant growth hormone) in children of short stature”. Paediatr Drugs (2002). 4 (1): 37–47. PMID 11817985. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11817985
 Low LC. “Growth hormone-releasing hormone: clinical studies and therapeutic aspects.” Neuroendocrinology. 1991;53 Suppl 1:37-40. Available from: http://www.ncbi.nlm.nih.gov/pubmed/1901390
 Alba-Roth J, Müller OA, Schopohl J, von Werder K. “Arginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion.” J Clin Endocrinol Metab. 1988 Dec;67(6):1186-9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/2903866
 Ronald S. Swerdloff, MD, Jason Ng, MD, and Gladys E. Palomeno, MD. “Gynecomastia: etiology, diagnosis, and treatment. March 2004. Ch. 14. Available from: http://www.endotext.org/male/male14/male14.html
 Does Fasting Build Muscle?” Men’s Health. April 2011. Available from: http://blogs.menshealth.com/health-headlines/fast-to-burn-fat-not-so-fast/2011/04/18
 Kanaley JA, Weltman JY, Veldhuis JD, Rogol AD, Hartman ML, Weltman A. “Human growth hormone response to repeated bouts of aerobic exercise.” J Appl Physiol. 1997 Nov;83(5):1756-61. Available from: http://www.ncbi.nlm.nih.gov/pubmed/9375348
 Van Cauter E, Latta F, Nedeltcheva A, Spiegel K, Leproult R, Vandenbril C, Weiss R, Mockel J, Legros JJ, Copinschi G. “Reciprocal interactions between the GH axis and sleep”. Growth Horm IGF Res. 2004 Jun;14 Suppl A:S10-7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15135771
 “Growth hormone Deficiency.” Boston Children’s Hospital. Available from: http://www.childrenshospital.org/az/Site971/mainpageS971P0.html
 “Growth hormone deficiency – children.” MedlinePlus. Available from: http://www.nlm.nih.gov/medlineplus/ency/article/001176.htm
 “Adult Growth Hormone Deficiency.” Cedars-Sinai. Available from: http://www.cedars-sinai.edu/Patients/Health-Conditions/Adult-Growth-Hormone-Deficiency.aspx
 “Gigantism.” Barrow Neurological Institute. Available from: http://www.thebarrow.org/Neurological_Services/Pituitary_Center/220073
 “What is Acromegaly? What Causes Acromegaly?” Medical News Today. Jun 9, 2011. Available from: http://www.medicalnewstoday.com/articles/227796.php
 “HGH: More Dangerous Health Gamble Than Fountain of Youth.” UW Health. Jan. 9, 2008. Available from: http://www.uwhealth.org/news/hgh-more-dangerous-health-gamble-than-fountain-of-youth/11939
 Zeman, ned. “Hollywoods’ Vial Bodies.” Vanity Fair. March 2012. Available from: http://www.vanityfair.com/hollywood/2012/03/human-grown-hormone-hollywood-201203
 Celizic, Mike. “Sylverster Stallone discusses HGH charge.” TODAY Entertainment. Jan 18, 2008. Available from: http://www.today.com/id/22728530/site/todayshow/ns/today-entertainment/t/sylvester-stallone-discusses-hgh-charge/#.UQmLh7872bM
 Fordyce, Tom. “Human growth hormone explained.” BBC Sport. July 27, 2003. Available from: http://news.bbc.co.uk/sport2/hi/front_page/3101343.stm
 “Growth Hormone: New method for extracting pituitary-gland secretion makes it possible to build muscle and bone in humans.” Life magazine. Oct 11, 1948. Available from: http://books.google.com/books?id=dEoEAAAAMBAJ&pg=PA89&lpg=PA89&dq=human+growth+hormone&source=bl&ots=7jfkT8mIfL&sig=fuLcTsEX2L-CrwEpjcPwcy9VLd4&hl=en&sa=X&ei=T7NkUPXnIdC30QHlrYHgBA&ved=0CDwQ6AEwAg#v=onepage&q&f=false
 “The big story behind synthetic human growth hormone.” National Museum of American History. Oct 18, 2012. Available from: http://blog.americanhistory.si.edu/osaycanyousee/2012/10/human-growth-hormone.html
 “Human Growth Hormone.” Drug Enforcement Administration. Aug. 2011. Available from: http://www.deadiversion.usdoj.gov/drugs_concern/hgh.pdf
 “Import Alert 66-71.” US Food and Drug Administration. March 18, 2011. Available from: http://www.accessdata.fda.gov/cms_ia/importalert_204.html
 “Growth Hormone.” WebMD. Available from: http://www.webmd.com/a-to-z-guides/growth-hormone
 Cohn L, Feller AG, Draper MW, Rudman IW, Rudman D. “Carpal tunnel syndrome and gynaecomastia during growth hormone treatment of elderly men with low circulating IGF-I concentrations.” Clin Endocrinol (Oxf). 1993 Oct;39(4):417-25. Available from: http://www.ncbi.nlm.nih.gov/pubmed/8287568
 Troels Krarup Hansen, Jens Møller, Klaus Thomsen, Erik Frandsen, Rolf Dall, Jens Otto Jørgensen, and Jens Sandahl Christiansen. “Effects of growth hormone on renal tubular handling of sodium in healthy humans.” AJP – Endo December 1, 2001 vol. 281 no. 6 E1326-E1332 Available from: http://ajpendo.physiology.org/content/281/6/E1326.full
 Drysdale, R. “Diabetes and HGH.” Health Guidance. Available from: http://www.healthguidance.org/entry/5837/1/Diabetes-and-HGH.html
 DeNoon, Daniel. “Growth Hormone Linked to Cancer.” WebMD Health News. July 25, 2002. Available from: http://www.webmd.com/colorectal-cancer/news/20020725/growth-hormone-linked-to-cancer
 “How to Use HGH.” HGH Medical Clinical. Available from: http://www.hgh.com.mx/how_to_use.html
 “HGH Frequently Asked Questions.” Anti-Aging Research Laboratories. Available from: http://www.antiagingresearch.com/HGH_faq_frequently_asked_questions.shtml
 “Growth Hormone and Growth Hormone Secretagogues.” DrLam.com. Available from: http://www.drlam.com/opinion/growth_hormone_and_growth_factors.asp
 Burke, Alex. “Definition of Secretagogues.” eHow Health. Available from: http://www.ehow.com/about_5406333_definition-secretagogues.html
 Wren AM, Small CJ, Ward HL, Murphy KG, Dakin CL, Taheri S, Kennedy AR, Roberts GH, Morgan DG, Ghatei MA, Bloom SR. “The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion.” Endocrinology. 2000 Nov;141(11):4325-8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11089570
 Alba-Roth J, Müller OA, Schopohl J, von Werder K. “Arginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion.” J Clin Endocrinol Metab. 1988 Dec;67(6):1186-9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/2903866
 Kanaley JA. “Growth hormone, arginine and exercise.” Curr Opin Clin Nutr Metab Care. 2008 Jan;11(1):50-4. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18090659
 A. Isidori, A. Lo Monaco and M. Cappa. “A study of growth hormone release in man after oral administration of amino acids.” 1981, Vol. 7, No. 7 , Pages 475-481. Available from: http://informahealthcare.com/doi/abs/10.1185/03007998109114287
 Shinichi Demura, Takayoshi Yamada, Shunsuke Yamaji, Miho Komatsu, Koji Morishita. “The effect of L-ornithine hydrochloride ingestion on human growth hormone secretion after strength training.” Advances in Bioscience and Biotechnology. Vol.1 No.1, April 2010 Available from: http://www.scirp.org/Journal/PaperInformation.aspx?paperID=1583
 Parr TB. “A new technique to elevate night time growth hormone release and a potential growth hormone feedback control loop.” Med Hypotheses. 2001 May;56(5):610-3. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11388776
 T C Welbourne. “Increased plasma bicarbonate and growth hormone after an oral glutamine load.” Am J Clin Nutr May 1995 vol. 61 no. 5 1058-1061 Available from: http://ajcn.nutrition.org/content/61/5/1058.abstract
 Chromiak JA, Antonio J. “Use of amino acids as growth hormone-releasing agents by athletes.” Nutrition. 2002 Jul-Aug;18(7-8):657-61. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12093449
 “Dietary Supplements: What You Need to Know.” Office of Dietary Supplements. Available from: http://ods.od.nih.gov/HealthInformation/DS_WhatYouNeedToKnow.aspx
 Perez, AJ. “New Hurdle for HGH Detection.” USA Today. May 28, 2008. Available from: http://usatoday30.usatoday.com/sports/2008-05-27-hgh-cover_N.htm
 “CPG Sec. 400.400 Conditions Under Which Homeopathic Drugs May be Marketed.” US Food and Drug Administration. Available from: http://www.fda.gov/ICECI/ComplianceManuals/CompliancePolicyGuidanceManual/ucm074360.htm
 J R Davidson, H Moldofsky, and F A Lue. “Growth hormone and cortisol secretion in relation to sleep and wakefulness.” J Psychiatry Neurosci. 1991 July; 16(2): 96–102. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1188300/
 Hanson, Pamela. “Deep Sleep Tied to Hormone Production.” Chicago Tribune News. Aug 16, 2000. Available from: http://articles.chicagotribune.com/2000-08-16/news/0008160337_1_eve-van-cauter-sleep-hgh
 Doheny, Kathleen. “Can’t Sleep? Adjust the Temperature.” WebMD the magazine- Feature. Available from: http://www.webmd.com/sleep-disorders/features/cant-sleep-adjust-the-temperature
 Jamieson, James, “In Pursuit of the Methuselah Factor. Available from: http://www.hgh-usa.com/optimizing_hgh_therapy_with_diet_and_exercise.htm
 Emanuelson, jerry. “Human Growth Hormone.” Chapter 5. Jan 28, 2012. Available from: http://www.futurescience.com/hgh.html
 Yeager, Selene. “Drinking and Exercise: How Alcohol Affects Your Body.” Women’s Health Magazine. Available from: http://www.womenshealthmag.com/health/drinking-and-exercise
 Godfrey RJ, Madgwick Z, Whyte GP. “The exercise-induced growth hormone response in athletes.” Sports Med. 2003;33(8):599-613. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12797841
 Krahn, Bruce. “Increase Growth Hormone Naturally.” The Lean Body. Available from: http://www.theleanbody.com/fat-loss-tips/increase-growth-hormone-naturally
 Daniel Rudman, M.D., Axel G. Feller, M.D., Hoskote S. Nagraj, M.D., Gregory A. Gergans, M.D., Pardee Y. Lalitha, M.D., Allen F. Goldberg, D.D.S., Robert A. Schlenker, Ph.D., Lester Cohn, M.D., Inge W. Rudman, B.S., and Dale E. Mattson, Ph.D. “Effects of Human Growth Hormone in Men over 60 Years Old.” N Engl J Med 1990; 323:1-6July 5, 1990DOI: 10.1056/NEJM199007053230101 Available from: http://www.nejm.org/doi/full/10.1056/NEJM199007053230101
 Adams, Amy. “No evidence growth hormone boosts athletic performance, Stanford analysis shows.” Stanford School of Medicine News Releases. Available from: http://med.stanford.edu/news_releases/2008/march/growth-hormone.html
 Ronca, Debra. “Does human growth hormone slow the aging process?” Discovery Fit & health. Available from: http://health.howstuffworks.com/wellness/aging/anti-aging-tips/hgh-aging3.htm
 Oz, Mehmet. “Human Growth Hormone, Pt. 1” Available from: http://www.doctoroz.com/videos/supercharge-your-body-human-growth-hormone-pt-1
 Brody, Jane. “A plus side for human growth hormone.” The New York Times. May 3, 2010. Available from: http://www.nytimes.com/2010/05/04/health/04brod.html?_r=0
 Ozawa K, Mizunuma H, Ozawa H, Ibuki Y. “Recombinant human growth hormone acts on intermediate-sized follicles and rescues growing follicles from atresia.” Endocr J. 1996 Feb;43(1):87-92. Available from: http://www.ncbi.nlm.nih.gov/pubmed/8732457
 Leese GP, Wallymahmed M, VanHeyningen C, Tames F, Wieringa G, MacFarlane IA. “HDL-cholesterol reductions associated with adult growth hormone replacement.” Clin Endocrinol (Oxf). 1998 Nov;49(5):673-7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/10197085
 Åsa Tivesten, Anna Barlind, Kenneth Caidahl, Natalia Klintland, Antonio Cittadini, Claes Ohlsson and Jörgen Isgaard. “Growth hormone-induced blood pressure decrease is associated with increased mRNA levels of the vascular smooth muscle KATP channel.” Journal of Endocrinology (2004) 183, 195–202. Available from: http://joe.endocrinology-journals.org/content/183/1/195.full.pdf
 Volterrani M, Giustina A, Manelli F, Cicoira MA, Lorusso R, Giordano A. “Role of growth hormone in chronic heart failure: therapeutic implications.” Ital Heart J. 2000 Nov;1(11):732-8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11110515
Aström C, Lindholm J. “Growth hormone-deficient young adults have decreased deep sleep.” Neuroendocrinology. 1990 Jan;51(1):82-4. Available from: http://www.ncbi.nlm.nih.gov/pubmed/2106091?dopt=Abstract
 Haqq AM, Stadler DD, Jackson RH, Rosenfeld RG, Purnell JQ, LaFranchi SH. “Effects of growth hormone on pulmonary function, sleep quality, behavior, cognition, growth velocity, body composition, and resting energy expenditure in Prader-Willi syndrome.” J Clin Endocrinol Metab. 2003 May;88(5):2206-12. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12727976
 McGAULEY, G.A.”Quality of Life Assessment Before and After Growth Hormone Treatment in Adults with Growth Hormone Deficiency.” Acta Paediatrica, (1989) 78: 70–72. doi: 10.1111/j.1651-2227.1989.tb11249.x Available from: http://onlinelibrary.wiley.com/doi/10.1111/j.1651-2227.1989.tb11249.x/abstract
 “HGH increases Immune System Function.” Available from: http://www.hgh10.com/hgh-increases-immune-system-function/
 Keith W. Kelley, Douglas A. Weigent, Ron Kooijman. “Protein hormones and immunity.” Brain, Behavior, and Immunity, Volume 21, Issue 4, May 2007, Pages 384–392 http://dx.doi.org/10.1016/j.bbi.2006.11.010. Available from: http://www.sciencedirect.com/science/article/pii/S0889159106003618
 D J O’Halloran, A Tsatsoulis, R W Whitehouse, S J Holmes, J E Adams and S M Shalet. “Increased bone density after recombinant human growth hormone (GH) therapy in adults with isolated GH deficiency.” The Journal of Clinical Endocrinology & Metabolism May 1, 1993 vol. 76 no. 5 1344-1348. Available from: http://jcem.endojournals.org/content/76/5/1344.short
 Canning, Andrea. “HGH – Human Growth Hormone – Injections Give Cuple new Energy, Enjoyment of Life.” Good Morning America. Aug 9, 2011. Available from: http://abcnews.go.com/Health/hgh-human-growth-hormone-injections-give-couple-energy/story?id=14260228
 Klatz, Ronald. Grow young with HGH. ISDN: 0694518344. Available from: http://www.mdagelesssolutions.com/Medical%20References%20Hormone%20Experts.pdf
 Z Laron and B Klinger. “Effect of insulin-like growth factor-I treatment on serum androgens and testicular and penile size in males with Laron syndrome (primary growth hormone resistance).” European Journal of Endocrinology (1998) 138 176–180. Available from: http://eje-online.org/content/138/2/176.full.pdf
 Becker AJ, Uckert S, Stief CG, Scheller F, Knapp WH, Hartmann U, Brabant G, Jonas U. “Serum levels of human growth hormone during different penile conditions in the cavernous and systemic blood of healthy men and patients with erectile dysfunction.” Urology. 2002 Apr;59(4):609-14. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11927337
 J. Gibney, J. D. Wallace, T. Spinks, L. Schnorr, A. Ranicar, R. C. Cuneo, S. Lockhart, K. G. Burnand, F. Salomon, P. H. Sonksen and D. Russell-Jones. “The Effects of 10 Years of Recombinant Human Growth Hormone (GH) in Adult GH-Deficient Patients.” The Journal of Clinical Endocrinology & Metabolism August 1, 1999 vol. 84 no. 8 2596-2602 Available from: http://jcem.endojournals.org/content/84/8/2596.short
 J.B Deijen, H de Boer, E.A van der Veen. “Cognitive changes during growth hormone replacement in adult men.”Psychoneuroendocrinology, Volume 23, Issue 1, January 1998, Pages 45–55. http://dx.doi.org/10.1016/S0306-4530(97)00092-9 Available from: http://www.sciencedirect.com/science/article/pii/S0306453097000929
 SONNTAG, W. E., LYNCH, C., THORNTON, P., KHAN, A., BENNETT, S. and INGRAM, R. “The effects of growth hormone and IGF-1 deficiency on cerebrovascular and brain ageing.” Journal of Anatomy, (2000) 197: 575–585. doi: 10.1046/j.1469-7580.2000.19740575.x Available from: http://onlinelibrary.wiley.com/doi/10.1046/j.1469-7580.2000.19740575.x/abstract
 James Gibney, Troels Wolthers, Gudmundur Johannsson, A. Margot Umpleby, and Ken K. Y. Ho. “Growth hormone and testosterone interact positively to enhance protein and energy metabolism in hypopituitary men.” AJP – Endo August 1, 2005 vol. 289 no. 2 E266-E271. Published online before print February 22, 2005, doi: 10.1152/ajpendo.00483.2004. Available from: http://ajpendo.physiology.org/content/289/2/E266.short
 Manthos G. Giannoulis, Peter H. Sonksen, Margot Umpleby, Louise Breen, Claire Pentecost, Martin Whyte, Carolyn V. McMillan, Clare Bradley and Finbarr C. Martin. “The Effects of Growth Hormone and/or Testosterone in Healthy Elderly Men: A Randomized Controlled Trial.” The Journal of Clinical Endocrinology & Metabolism February 1, 2006 vol. 91 no. 2 477-484. Published online before print December 6, 2005, doi: 10.1210/jc.2005-0957. Available from: http://jcem.endojournals.org/content/91/2/477.long
 Brott, Harriet. “Dr. Feel Young.” Self Magazine. Available from: http://www.self.com/health/2009/08/risky-hormone-use
 Myers, Christi. “Women taking HGH for looks.” ABC Local news. June 22, 2009. Available from: http://abclocal.go.com/ktrk/story?section=news/health&id=5951308
 Epstein, Samuel. “Anti-Aging Medicine (HGH) increases cancer risks.” Cancer Prevention Coalition. Press Release. March 14, 2000. Available from: http://www.preventcancer.com/patients/med_avoid/hgh.htm
 Authors: Erotokritou-Mulligan I, Holt RI, Sönksen PH. “Growth hormone doping: a review.” Published Date July 2011 Volume 2011:2. Pages 99 – 111 DOI: http://dx.doi.org/10.2147/OAJSM.S11626/ Available from: http://www.dovepress.com/growth-hormone-doping-a-review-peer-reviewed-article-OAJSM
 Liu H, Bravata DM, Olkin I, Friedlander A, Liu V, Roberts B, Bendavid E, Saynina O, Salpeter SR, Garber AM, Hoffman AR. “Systematic review: the effects of growth hormone on athletic performance.” Ann Intern Med. 2008 May 20;148(10):747-58. Epub 2008 Mar 17. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18347346
 Robson, David. “Steroid Undercover: a pro bodybuilder tells all about his steroid use.” Oct 13, 2006. Available from: http://www.bodybuilding.com/fun/drobson221.htm
 DeNoon, Daniel. “Doping With Muscle-Building Drugs: FAQ.” WebMD Health News. July 13, 2012. Available from : http://www.webmd.com/fitness-exercise/news/20120713/doping-muscle-building-drugs-faq
 M Saugy, N Robinson, C Saudan, N Baume, L Avois, P Mangin. “Human growth hormone doping in sport.” Br J Sports Med 2006;40:i35-i39 doi:10.1136/bjsm.2006.027573. Available from: http://bjsm.bmj.com/content/40/suppl_1/i35.abstract
 Perez, AJ. “Scientists say breakthrough urine test for HGH developed.” USA Today. July 23, 2008. Available from: http://usatoday30.usatoday.com/sports/2008-07-22-hgh-urine-test_N.htm
 Davidson, Craig. “Miracle.” Esquire.com. March 29, 2012. Available from: http://www.esquire.com/features/hormone-replacement-therapy-men-2
 “HGH Testosterone Therapy.” Kingsberg Medical. Available from: http://www.hgh1.com/hgh-testosterone/
 Schedel JM, Tanaka H, Kiyonaga A, Shindo M, Schutz Y. “Acute creatine loading enhances human growth hormone secretion.” J Sports Med Phys Fitness. 2000 Dec;40(4):336-42. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11297004
 A Golander, I. Binderman, A.M. Kaye, A. Nimrod, and D. Somjen. “Stimulation of Creatine Kinase Activity in Rat Organs by Human Growth Hormone in Vivo and in Vitro*” Endocrinology May 1, 1986 vol. 118 no. 5 1966-1970. doi: 10.1210/endo-118-5-1966. Available from: http://endo.endojournals.org/content/118/5/1966.short
 Hoffman, Ronald. “Natural hormones: longevity drugs of the future.” Available from: http://www.drhoffman.com/page.cfm/92
 Genazzani AD, Stomati M, Strucchi C, Puccetti S, Luisi S, Genazzani AR. “Oral dehydroepiandrosterone supplementation modulates spontaneous and growth hormone-releasing hormone-induced growth hormone and insulin-like growth factor-1 secretion in early and late postmenopausal women.” Fertil Steril. 2001 Aug;76(2):241-8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11476767
 Brooke AM, Kalingag LA, Miraki-Moud F, Camacho-Hübner C, Maher KT, Walker DM, Hinson JP, Monson JP. “Dehydroepiandrosterone improves psychological well-being in male and female hypopituitary patients on maintenance growth hormone replacement.” J Clin Endocrinol Metab. 2006 Oct;91(10):3773-9. Epub 2006 Jul 18. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16849414
 Shaonin Ji, Ran Guan, Stuart J. Frank, and Joseph L. Messina. “Insulin Inhibits Growth Hormone Signaling via the Growth Hormone Receptor/JAK2/STAT5B Pathway.” May 7, 1999 The Journal of Biological Chemistry, 274, 13434-13442. doi: 10.1074/jbc.274.19.13434. Available from: http://www.jbc.org/content/274/19/13434.short
 Xu J, Ji S, Venable DY, Franklin JL, Messina JL. “Prolonged insulin treatment inhibits GH signaling via STAT3 and STAT1.” J Endocrinol. 2005 Mar;184(3):481-92. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15749807
 Shoshana Yakar, Jennifer Setser, Hong Zhao, Bethel Stannard, Martin Haluzik, Vaida Glatt, Mary L Bouxsein, John J. Kopchickand Derek LeRoith. “Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1–deficient mice.” J Clin Invest. 2004;113(1):96–105. doi:10.1172/JCI17763. Available from: http://www.jci.org/articles/view/17763
 R I G Holt, and P H Sönksen. “Growth hormone, IGF-I and insulin and their abuse in sport.” Br J Pharmacol. 2008 June; 154(3): 542–556. Published online 2008 March 31. doi: 10.1038/bjp.2008.99. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2439509/
 “Human Growth Hormone – An Anti-Aging Miracle?” Infographics Showcase. Available from: http://www.infographicsshowcase.com/human-growth-hormone-an-anti-aging-miracle/
Barret, Stephen. “Growth Hormone Schemes and Scams.” QuackWatch. Available from: http://www.quackwatch.org/01QuackeryRelatedTopics/hgh.html
 “Don’t Get Scammed!” The Anti Aging Guide 2013. Available from: http://antiagingguide.com/human_growth_hormone_scams.htm
 “HGH Scams and things to watch for.” Somatropin.net. Available from: http://www.somatropin.net/hgh-scams.htm
 “Inspections, Compliance, Enforcement, and Criminal Investigations.” US Food and Drug Administration. June 10, 2010. Available from: http://www.fda.gov/ICECI/EnforcementActions/WarningLetters/ucm217073.htm